海南医科大学学报

氧疗对24例皮片缺血患者的疗效观察

目的:探讨植皮后皮片缺血的原因及防护措施。方法:回顾性分析24例局部性皮片缺血患者,采用氧气对缺血区吹气法。结果:24例患者中,22例治疗2 d后皮片缺血区开始缩小,7 d后皮片缺血区皮肤颜色恢复正常。2例足部移植皮片,坏死区域扩大。结论:氧疗对植皮后缺血区有帮助恢复功能,缩短了植皮后缺血代偿时间,有利于皮片在移植受区的存活。

原发性肺癌的影像学误诊分析

目的:探讨原发性肺癌的影像学误诊原因,以提高影像诊断水平。方法:回顾性分析65例影像学误诊的原发性肺癌的临床和影像学表现,所有病例均经病理或细胞学证实。结果:影像学表现不典型或临床症状无特异性,经验不足,影像检查不全面是误诊的主要原因。结论:掌握肺癌的影像学和临床特点,多种影像检查结合,以及影像与临床结合分析是提高诊断水平,减少误诊的主要措施。

DNA damage in exfoliated buccal cells and antioxidant status of saliva in brain tumour patients

The present investigation was carried out in exfoliated buccal cells and saliva collected from pre-operative brain tumour patients. The DNA damage in these cells was assessed by alkaline comet assay and micronucleus (MN) assay. Salivary flow rate, pH, osmolality, total antioxidant activity (AOA) and vitamin C levels were also assessed in unstimulated whole saliva of these patients. In the comet assay a significant increase in the tail length (P<0.02) was observed when control and malignant groups were compared. A significant (P<0.02) difference in tail length was also noted between benign and malignant groups. Non significant results were found when control and benign groups were compared. Further, a marked increase in % MN (P<0.002) was observed when control and benign groups were compared. A significant increase in % MN (P<0.029) was also observed in benign cases when compared to malignant tumours. No significance was obtained when % MN in control and malignant cases was compared. Moreover, salivary flow rate and pH was significantly decreased and osmolality was markedly increased in brain tumour patients. The AOA levels in saliva were markedly decreased in brain tumours and vitamin C levels exhibited no change when compared to controls. Thus, as noted above susceptibility to free radical induced DNA damage also exists in the exfoliated buccal cells conducive to the lowered salivary antioxidant status of brain tumour patients.

多沙普仑催醒引起肺水肿1例报告

米非司酮、米索前列醇应用于人流钳刮术51例临床观察

Neonatal mortality in a tertiary hospital in Southern Nigeria

Objective: With improved and sustained efforts in the prevention and management of pneumonia, diarrhea and vaccine preventable diseases, neonatal mortality is increasingly becoming a major contributor to childhood mortality particularly in developing countries. Evaluation of neonatal mortality pattern is an essential step in the effort to curb its incidence. We therefore, set out to determine the neonatal mortality pattern and its associated factors in a tertiary hospital in southern Nigeria. Methods: This is a retrospective study of neonatal mortality in a tertiary hospital from August 2004 to July 2007(a 3 year period). Data obtained include total live births, neonatal deaths, relevant information on pregnancy, labour and delivery, neonatal morbidity and duration of life. Results: There were a total of 3,051 live births and 44 neonatal deaths with a neonatal mortality rate of 14.4/1000 live births. Early neonatal mortality constituted 81.8%of over all neonatal mortality with the major causes being prematurity 40% severe birth asphyxia 29.5%and neonatal sepsis 18.3%. Low birth weight babies (<2500 grams) constituted 55.5% of total neonatal mortality. Conclusion: Early neonatal mortality constitutes an overwhelming proportion of neonatal mortality in Southern Nigeria. This can be significantly curtailed by reducing the incidence and death from prematurity, severe birth asphyxia and neonatal sepsis.

晚发性维生素K缺乏症致颅内出血的治疗——附20例分析

抑癌基因HIC-1甲基化状态在宫颈癌Hela细胞中的研究

目的:观察特异性甲基转移酶抑制剂5-氮脱氧胞苷(5-Aza-deoxycytidine)对宫颈癌Hela细胞株中HIC-1、P53启动子的去甲基化作用,对细胞增殖的影响,探讨P53与HIC-1之间的关系,以及HIC-1基因甲基化状态在宫颈肿瘤中的作用。方法:分别使用5、10、20μmol/L的5-Aza-CdR作用Hela细胞株1、3、5d,采用半定量RT-PCR检测P53、HPV、HIC-1表达的改变;用四甲基偶氮唑蓝法和直接计数法检测细胞生长与增殖状况。结果:Hela细胞株经三种不同浓度的5-Aza-CdR作用5d后Hela细胞形态上无明显改变;经药物处理后,细胞生长活力(A490值)受到不同程度的抑制,其作用在所检测的浓度范围内随5-Aza-CdR浓度的增加而增加,呈量效关系;5-Aza-CdR可有效上调HIC-1、P53基因在Hela细胞中的表达,并随浓度递增;而5-Aza-CdR干预前后,HPV18E6mRNA表达无明显改变。结论:HIC-1可能作为抑癌基因在宫颈癌的发生、发展中发挥重要作用,甲基化是调控其表达下调的重要机制,通过去甲基化有可能抑制宫颈癌病程进展。

The impact of socioeconomic status on growth during infancy versus puberty in a developing country

Objective:To explore the relationship between socioeconomic status from one side and physical growth and nutritional status from the other side,in infants versus adolescents in Egyptians.Methods:Three samples were investigated:a)A sample of 605 infants aged 6 months+1 week(287 girls and 318 boys).b)A sample of 992 infants of age 4~24 months(465 girls and 527 boys).c)A sample of 1864 children and adolescents aged 6~14 years of(744 girls and 1120 boys).All samples are from Big Cairo area of both urban and rural localities and of various socioeconomic strata.Body weight and length/height had been measured and body mass index(BMI)had been calculated for every subject.Assessment of the impact of parental education level,locality and number of sibs,on growth and nutrition as indicated by BMI was attempted.Results:a)Breastfed infants(6 months +1 week)grow bigger in low socioeconomic strata and in rural areas than artificially fed infants.The practice of breast feeding was more common and lasted longer in low socioeconomic stratum than in middle and high one.b)A significant positive association between body mass index of infants(4～24 months)and the socioeconomic status(particularly level of father education reflecting family income)was proved.c)The socioeconomic factors had insignificant influence on BMI of school children aged 6～9 years,but it showed significant influence in the period 10 ～ 14 years.After the age of 9 years,children started the pubertal stage earlier and had higher BMI in the high socioeconomic strata as compared to those of low socioeconomic strata.d)In the low socioeconomic status,breast feeding compensates the deleterious influences of the environment on growth and physique of infants.Conclusion:children of educated parents have significantly low number of siblings' size in comparison to those of uneducated parents.Also children of educated parents are significantly more in number in urban areas than in rural areas,and vice versa.The interdependence between parental education and locality shows the highest level of significance in both sexes and at all ages.

《海南医学院学报》2006年第12卷篇名索引

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