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目的:探讨吡美莫司乳膏治疗对皮炎湿疹患者血清炎性因子及免疫功能的影响。方法:选取来我院诊治的皮炎湿疹患者112例,依据随机数据表法分为对照组及观察组,每组各56例。对照组采用丁酸氢化可的松软膏治疗,观察组采用1%吡美莫司乳膏治疗,观察并比较两组患者治疗前及治疗1个月后,两组炎性因子干扰素-γ(IFN-γ)、白介素-4(IL-4)和白介素-10(IL-10)水平和免疫功能(T淋巴细胞亚群CD3+、CD4+、CD8+)相关指标变化。结果:炎性因子水平比较:两组治疗后IFN-γ、IL-4、IL-10水平与同组治疗前水平相比均不同程度降低,且治疗后观察组IFN-γ、IL-4、IL-10水平要低于对照组,差异均具有统计学意义(P<0.05);免疫功能水平比较:两组治疗后CD3+、CD4+水平与同组治疗前相比均显著升高,且治疗后观察组CD3+、CD4+水平要高于对照组,差异均具有统计学意义(P<0.05);两组治疗后CD8+浓度与同组治疗前相比显著下降,且治疗后观察组CD8+水平要低于对照组治疗后,差异均具有统计学意义(P<0.05)。结论:1%吡美莫司乳膏治疗可以有效改善皮炎湿疹患者的血清炎性因子水平及免疫功能,值得临床推广。
Abstract：Objective:To investigate influence of Pimecrilimus Cream therapy on serum inflammatory factors and immune function of patients with eczematous dermatitis.Methods:A total of 112 cases of patients with eczematous dermatitis treated in our hospital from March 2015 to May 2016 were selected and randomly divided into the control group and observation group with 56 cases each.For control group,Hydrocortisone butyrate onitment therapy was utilized.For observation group,1% Pimecrilimus cream was used for treatment.Variations of interferon inflammation factors-γ(IFN-γ),interleukin-4(IL-4),interleukin-10(IL-10)levels and immune function(T lymphocyte subsets CD3+,CD4+,CD8+)relevant indexes in two groups of patients before and one month after treatment were observed and compared.Results:Comparison of inflammatory factor levels:IFN-γ,IL-4and IL-10 levels in two groups of patients after treatment were decreased with different extent comparing with the same group before treatment,differences were significant(P<0.05).IFN-γ,IL-4and IL-10 levels in observation group(31.27±6.45)ng/L,(30.54±5.64)ng/L,(38.66±4.73)ng/L were lower than levels in control group after treatment(37.49±5.69)ng/L,(36.44±5.51)ng/L,(55.31±4.62)ng/L,differences were significant(P<0.05);Comparison of immune function levels:CD3~+and CD4~+levels in two groups of patients after treatment were significantly increased comparing with the same group before treatment(P<0.05),CD3+,CD4~+levels in observation group after treatment 65.53%±3.31%,34.55%±2.27% were higher than levels in control group after treatment(60.38%±3.16%,32.65±2.16%,differences were significant(P<0.05);Levels of CD8~+concentration in two groups of patients after treatment were significantly decreased comparing with the same group before treatment(P <0.05).CD8~+levels in observation group after treatment(24.17% ±2.05%)were lower than control group after treatment(27.63% ±2.46 %),differences were significant(P<0.05).Conclusions:One percent Pimecrilimus cream treatment could effectively improve serum inflammatory factor levels and immune function of patients with eczematous dermatitis,which deserved clinical expansion.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20170113.005
中图分类号:R758.23
引用信息:
[1]周洋,曹丽华,文晓婷.吡美莫司乳膏治疗对皮炎湿疹患者血清炎性因子及免疫功能水平影响[J].海南医学院学报,2017,23(08):1146-1148+1152.DOI:10.13210/j.cnki.jhmu.20170113.005.
基金信息:
江苏省自然科学基金面上项目(MS2015299)~~
2017-01-13
2017-01-13
2017-01-13