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目的:探讨凋亡相关基因Survivin、Bcl-2在甲状腺乳头状癌组织中的表达与临床病理特征之间的关系。方法:应用免疫组织化学方法,检测Survivin、Bcl-2在102例甲状腺乳头状癌组织及20例结节性甲状腺肿组织中的表达。结果:102例甲状腺乳头状癌组织中Survivin、Bcl-2阳性表达率分别为66.7%(68/102)和81.0%(83/102),而良性病变组织中分别为20.0%(4/20)和95.0%(19/20)(P<0.05),结论:在甲状腺乳头状癌组织中survivin表达显著上调,Bcl-2下调。Survivin表达与Bcl-2正相关,Bcl-2表达量的高低与分化程度正相关。survivin及Bcl-2表达与淋巴结转移有关。
Abstract：Objective: To investigate the gene expressions of both Bcl-2 and survivin in thyroid papillary carcinoma and their relationship with clinic pathological features.Methods: The expressions of Bcl-2 and survivin were determined by immunohistochemistry method in 102 cases of thyroid papillary caricinoma and 20 thyroid nodular goiter.Results: The positive rates of survivin and Bcl-2 were 66.7%(68/102) and 81%(83/102) respectively in thyroid papillary carcinoma compared to that were 30% (4/20) and 95%(19/20) respectirely in benign lesion group(P<0.05). Conclusion: The expression of survivin is up-regulated in thyroid papillary caricinoma while Bcl-2 down-regulated.The survivin expression is positive correlation with Bcl-2 expression,but Bcl-2 expression is positive correlation with differentiation degree of cells.The expressions of both Bcl-2 and survivin in thyroid papillary carcinoma are associated with lymph nodes metastasis.
1 Hedinger C,Williams ED,Sobin LH.1988 Histological typ-ing of thyroid tumours[M].2nd.Berlin:Springer-Verlag,2003.9-11.
2 Okada H,Mak TW.Pathways of apoptosis and non-apopto-sis death in tumour cells[J].Net Rev Cancer,2004,4(8):592-603.
3 Ito Y,Yoshida H,Uruno T,et al.Survivin expression issignificantly linked to the dedifferentiation of thyroid carcino-ma[J].Oncol Rep,2003,10(5):1337-1340.
4 Aksov M,Giles Y,Kapran Y,et al.Expression of bcl-2 inpapillary thyroid cancers and its prognostic value[J].ActaChir Belg,2005,105(6):644-664.
5 Kawasaki H,Altieri DC,Lu CD,et al.Inhibition of apopto-sis by survivin predicts shorter survivial rates in colorectalcancer[J].Cancer Res,1998,58(22):5071-5074.
6 Basolo F,Fiore L,Fusco A,et al.Potentiation of the malig-nant phenotype of the undifferentiated ARO thyroid cell lineby insertion of the bcl-2 gene[J].Int J Cancer,1999,81(6):956-962.
7 Wang W.Apoptosis and expression of the Proto-Oncogenesbcl-2 and p53 and the Proliferation Factor Ki-67 in humanmedullary thyroid carcinoma[J].Endocr Pathol,1996,7(1):37-45.
基本信息:
DOI：10.13210/j.cnki.jhmu.2007.06.032
中图分类号:R736.1
引用信息:
[1]刘军,陈江,崔彬.Bcl-2、Survivin在甲状腺乳头状癌组织中的表达及意义[J].海南医学院学报,2007,No.61(06):518-520.DOI:10.13210/j.cnki.jhmu.2007.06.032.
2007-12-28
2007-12-28