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目的:探讨舌下含服硝苯地平和静脉注射乌拉地尔治疗高血压急症的疗效。方法:回顾性分析2008年8月～2011年5月我院收治的高血压急症患者195例,其中舌下含服硝苯地平125例,静脉注射乌拉地尔70例,观察两组用药前后血压、心率的变化。结果:乌拉地尔组血压在用药后5min即明显下降(P<0.05),30min达到高峰并保持稳定,总有效率为92.9%,心率无明显改变(P>0.05);硝苯地平组血压在用药后5min开始下降,30min达到高峰(P<0.05),在3h有上升趋势,总有效率为77.6%,心率在血压下降同时有所增加(P<0.05)。乌拉地尔组降压疗效明显好于硝苯地平组(P<0.05)。结论:静脉注射乌拉地尔治疗效果优于舌下含服硝苯地平,更适合于高血压急症的治疗。
Abstract：Objective: To evaluate the clinical efficacy and safety of sublingual administration of nifedipine and intravenous injection of urapidil in the treatment of hypertensive emergency.Methods: A total of 195 patients with hypertensive emergency admitted from August 2008 to May 2011 were selected,among whom 125 were treated with blingual administration of nifedipine and 70 with intravenous injection of urapidil.The changes of blood pressure(systolic blood pressure and diastolic blood pressure) and heart rate at the time before injection and 5 min,10 min,30 min,60 min,120 min,180 min after administration were observed.Results: In urapidil group,the blood pressure significantly dropped 5 min after injection(P<0.05),and reached and maintained the maximal peak 30 min after injection.The total efficacy was 92.9%,and no change of heart rate was observed.In nifedipine group,the blood pressure started to drop 5 min after injection(P<0.05),and reached the maximal peak 30 min after injection,but began to elevate at 3 h.The total efficacy was 77.6%,and heart rate was increased as decreasing blood pressure.Conclusions: Intravenous injection of urapidil shows better therapeutic effect than sublingual administration of nifedipine and is more suitable for the treatment of hypertensive emergency
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基本信息:
DOI：10.13210/j.cnki.jhmu.2012.01.024
中图分类号:R544.1
引用信息:
[1]龚尤贵.舌下含服硝苯地平和静脉注射乌拉地尔治疗高血压急症的疗效观察[J].海南医学院学报,2012,18(01):35-37.DOI:10.13210/j.cnki.jhmu.2012.01.024.
基金信息:
海南医学院科研基金资助学报项目(0020120008)~~
2011-11-12
2011-11-12
2011-11-12