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目的:研究胆舒胶囊联合喜炎平治疗急性胆囊炎的机制,为急性胆囊炎患者的临床治疗提供更好的帮助。方法:选取门诊治疗的180例急性胆囊炎患者,随机将患者分为联合治疗组和对照组,每组90例,对照组患者采用常规治疗,联合治疗组在常规治疗基础上给予胆舒胶囊联合喜炎平的治疗。治疗前后检测并分析各组患者免疫细胞、胆囊炎相关指标、炎症因子和凝血功能相关指标。结果:与治疗前相比,两组患者经治疗后凝血功能指标[凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)]、CD8+、胆囊炎相关指标[总胆红素、淀粉酶以及降钙素原(PCT)]、炎症因子[超敏C-反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和白介素-10(IL-10)]显著降低,血清前白蛋白(PA)、免疫细胞(CD3+、CD4+和CD4+/CD8+)显著升高,差异存在统计学意义(P<0.05);凝血酶时间(TT)和纤维蛋白原(FIB)水平变化不明显(P>0.05)。与治疗后对照组相比,治疗后的联合治疗组凝血功能指标(PT和APPT)、CD8+、胆囊炎相关指标(总胆红素、淀粉酶以及PCT)、炎症因子(hs-CRP、TNF-α、IL-6和IL-10)显著降低,PA、免疫细胞(CD3+、CD4+和CD4+/CD8+)显著升高,差异存在统计学意义(P<0.05);TT以及FIB水平变化不明显(P>0.05)。结论:胆舒胶囊联合喜炎平能够显著改善急性胆囊炎患者免疫细胞、胆囊炎相关指标、炎症因子和凝血功能相关指标,对急性胆囊炎患者的治疗具有积极的临床意义。
Abstract：Objective:To observe the mechanism of Danshu capsules combined with Xiyanping for acute cholecystitis treatment in order to find better treatments for acute cholecystitis.Methods:A total of 180 patients with acute cholecystitis were selected and randomly divided into groups:the observation group(90people)and the control group(90people).The patient in the control group were treated with conventional therapy and the patients in the observation group were treated with Danshu capsules combined with Xiyanping on the basis of conventional therapy.Immunological cell,cholecystitis related factors,inflammatory factors,and the coagulation function related factors were detected and analyzed before and after treatment.Results:Coagulation function related factors(PT and APTT),CD8+,cholecystitis related factors(total bilirubin,amylase and PCT),inflammatory factor(hs-CRP、TNF-α、IL-6和IL-10)in both groups after treatment significantly decreased.PA,immunological cell(CD3+,CD4~+and CD4+/CD8+)significantly increased compared with that before treatment.The difference before and after treatment was considered to be statistically significant(P<0.05).PP and the changes of FIB were not statistically significant(P>0.05).Coagulation function related factors(PT and APTT),CD8+,cholecystitis related factors(total bilirubin,amylase and PCT),and inflammatory factor(hs-CRP、TNF-α、IL-6和IL-10)in observation group after treatment decreased more significantly than that in control group,it was considered to be statistically significant(P<0.05).Conclusion:Danshu capsules combined with Xiyanping can perfect effectively immunological cell,cholecystitis related factors,inflammatory factors and coagulation function related factors on patients with acute cholecystitis,it has important clinical significance for acute cholecystitis.
1 Trnqvist B,Waage A,Zheng Z,et al.Severity of acute cholecystitis and risk of iatrogenic bile duct injury during cholecystectomy,apopulation-based case-control study[J].World J Surg,2016,40(5):1060-1067.
2 De MC,Rotstein OD,Laupacis A,et al.Comparative operative outcomes of early and delayed cholecystectomy for acute cholecystitis:apopulation-based propensity score analysis[J].Ann Surg,2014,259(1):10-15.
3 李世忠.急诊手术联合生长抑素治疗急性胆囊炎对患者炎症状态、肝功能水平的影响[J].海南医学院学报,2016,22(15):1646-1648.
4 Haas I,Lahat E,Griton Y,et al.Percutaneous aspiration of the gall bladder for the treatment of acute cholecystitis:aprospective study[J].Surg Endosc,2016,30(5):1948-1951.
5 Gargya V,Smolarek S,Walsh TN.Concerns about acute cholecystitis:early versus delayed cholecystectomy-a multicenter randomized trial[J].Ann Surg,2014,262(2):251-261.
6 Badia JM,Nve E,Jimeno J,et al.Surgical management of acute cholecystitis.Results of a nation-wide survey among Spanish surgeons[J].Cirugía Espaola,2014,92(8):517-524.
7 Skandalakis JE.Management of acute cholecystitis[J].Curr Opin Infect Dis,2016,47(47):79-82.
8 Wu JX,Nguyen AT,Virgilio CD,et al.Can it wait until morning?A comparison of nighttime versus daytime cholecystectomy for acute cholecystitis[J].Am J Surg,2014,208(6):917-918.
9 Hwang H,Marsh I,Doyle J.Does ultrasonography accurately diagnose acute cholecystitis?Improving diagnostic accuracy based on a review at a regional hospital[J].Can J Surg,2014,57(3):162-168.
10 Liau KH,Teh C,Serrablo A.Management of acute cholecystitis and acute cholangitis in emergency setting[J].Cent Eur J Med,2014,9(3):357-369.
11 Jayakrishnan TT,Groeschl RT,George B,et al.Review of the impact of antineoplastic therapies on the risk for cholelithiasis and acute cholecystitis[J].Ann Surg Oncol,2014,21(1):240-247.
12 Teixeira J,Ribeiro C,Moreira LM,et al.Laparoscopic cholecystectomy and open cholecystectomy in acute cholecystitis:critical analysis of 520cases[J].Acta Medica Port,2014,27(6):685-691.
13 Shao P,Zhang TA,Zhang Z,et al.Numerical simulation on gas-liquid flow in mechanical-gas injection coupled stirred system[J].ISIJ Int,2014,54(7):1507-1516.
14 唐天雄.喜炎平在小儿轮状病毒腹泻治疗中的应用[J].海南医学院学报,2016,22(13):1436-1437.
15 张秋枫,孙燕.喜炎平治疗小儿轮状病毒性肠炎123例疗效观察[J].贵州医药,2014,38(6):534-536.
16 Hu G,Yuan X,Zhang S,et al.Research on choleretic effect of menthol,menthone,pluegone,isomenthone,and limonene in DanShu capsule[J].Int Immunopharmacol,2014,24(2):191-197.
17 吕晶,陆文熊.腹腔镜胆囊切除术在老年患者中的应用评价[J].实用老年医学,2014,28(12):1050-1051.
19 Xiong N,Wang X,Liu X,et al.Effect of the combination of Xiyanping and cefazolin on the function of neutrophils in mice[J].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi,2015,32(5):1079-1082.
20 Yin XP,Xie YM,Zhi YJ,et al.Correlation analysis on combined medication with of Xiyanping injection in treatment of lung infection in real world[J].Zhongguo Zhong Yao Za Zhi,2015,40(12):2440-2444.
21 Wang ZF,Huo J,Xie YM.Analysis of actual effects of combining Xiyanping injection with vitamin C injection in treatment of upper respiratory tract infection[J].Zhongguo Zhong Yao Za Zhi,2013,38(18):3161-3165.
基本信息:
DOI：10.13210/j.cnki.jhmu.20161008.013
中图分类号:R575.61
引用信息:
[1]王宏亮,袁吕荣,刘亚明.胆舒胶囊联合喜炎平治疗急性胆囊炎的机制研究[J].海南医学院学报,2016,22(23):2847-2850.DOI:10.13210/j.cnki.jhmu.20161008.013.
基金信息:
江苏省卫生厅课题(JB201599)~~
2016-10-08
2016-10-08
2016-10-08