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口腔鳞状细胞癌(oral squamous cells carcinoma, OSCC)是口腔颌面部最常见的恶性肿瘤,肿瘤间质细胞与肿瘤细胞之间的相互作用参与肿瘤细胞的增殖、分化、凋亡、黏附及迁移等过程并且与肿瘤的恶性程度及预后密切相关,了解肿瘤间质细胞来源及其对肿瘤发生发展的影响对OSCC的治疗具有重要意义。本文总结了几种重要肿瘤间质细胞的来源及其对肿瘤细胞的作用,以期为OSCC的治疗提供帮助。
Abstract：Objective: Oral squamous cell carcinoma(OSCC) is the most common malignant tumour in oral and maxillofacial region. The interaction between stromal cells and tumor cells is involved in the proliferation, differentiation, apoptosis, adhesion and migration of tumor cells, and is closely related to the malignant degree and prognosis of tumors. The development of OSCC is of great significance to the treatment of OSCC. This paper summarizes the sources of several important stromal cells and their effects on tumor cells, which provides a theoretical basis for the treatment of OSCC.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20190304.002
中图分类号:R739.8
引用信息:
[1]陈雨蒙,徐晓薇,刘欣辰,等.肿瘤间质细胞对口腔癌作用的研究进展[J].海南医学院学报,2019,25(07):552-556.DOI:10.13210/j.cnki.jhmu.20190304.002.
基金信息:
国家自然科学基金资助项目(81320108011); 吉林省省级产业创新专项资金项目(2016C044-3); 吉林省自然科学基金(20170101093JC)~~
2019-03-07
2019-03-07
2019-03-07