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目的:探讨血清肿瘤标志物和细胞因子在乳腺癌检测中的临床意义。方法:选取不同分期的乳腺癌患者586例,良性乳腺疾病患者250例,健康对照250例,检测并比较其血清肿瘤标志物(CA125、CA153、CA199、CEA、β-hCG、CYFRA21-1、TPS)和细胞因子(TNF-α、IL-6、IL-8、GDF3)水平。结果:不同分期的乳腺癌各组的血清肿瘤标志物(CA125、CA153、CA199、CEA、β-hCG、CYFRA21-1、TPS)和细胞因子(TNF-α、IL-6、IL-8、GDF3)水平均高于对照组及良性乳腺疾病组(均P<0.05),不同分期的乳腺癌各组之间的血清肿瘤标志物和细胞因子水平比较差异均具有统计学意义(均P<0.05),随着分期的升高,其血清肿瘤标志物均升高,以Ⅳ期乳腺癌组为最高,未发现对照组及良性乳腺疾病组之间各血清肿瘤标志物和细胞因子差异存在统计学意义(均P>0.05)。结论:血清肿瘤标志物(CA125、CA153、CA199、CEA、β-hCG、CYFRA21-1、TPS)及细胞因子(TNF-α、IL-6、IL-8、GDF3)在乳腺癌检测中具有重要的临床意义。
Abstract：Objective:To explore the clinical significance of serum tumor markers and cytokines in the detection of breast cancer.Methods:A total of 586 different breast cancer staging,250 patients with benign breast disease and 250 controls were detected and compared in terms of the serum tumor markers(CA125,CA153,CA199,CEA,β-hCG,CYFRA21-1,TPS)and cytokines(TNF-α,IL-6,IL-8,GDF3)level.Results:The serum tumor staging of breast cancer were different markers(CA125,CA153,CA199,CEA,β-hCG,CYFRA21-1,TPS)and cytokines(TNF-α,IL-6,IL-8,GDF3)were significantly higher than those in control group and benign breast disease group(P<0.05);serum tumor between different groups of breast cancer staging markers and cytokine levels were statistically different(P<0.05);with the staging elevating,serum tumor markers were increased and stageⅣ breast cancer group was the highest;there was no significant difference between the control group and the benign breast disease group in terms of serum tumor markers and cytokine(P>0.05).Conclusions:Serum tumor markers(CA125,CA153,CA199,CEA,β-hCG,CYFRA21-1,TPS)and cytokines(TNF-α,IL-6,IL-8,GDF3)in breast cancer detection have important clinical significance.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20161230.005
中图分类号:R737.9;R730.43
引用信息:
[1]孙小涵,曹勤,肖建英.血清肿瘤标志物和细胞因子在乳腺癌检测中的临床意义研究[J].海南医学院学报,2017,23(02):197-200.DOI:10.13210/j.cnki.jhmu.20161230.005.
基金信息:
辽宁省自然科学基金项目(201511290)~~
2016-12-30
2016-12-30
2016-12-30