海南医科大学学报

目的:探讨不同分期的糖尿病视网膜病变与血糖、血脂、血压、尿微量白蛋白/肌酐比值等的相关关系,为糖尿病视网膜病变的发病机制及综合防治提供科学依据。方法:收集我院内分泌科住院的2型糖尿病患者196例,将其分为无视网膜病变组180例,非增殖期视网膜病变组11例,增殖期视网膜病变组5例,并设正常人群对照组40例。每个被调查对象均进行眼底彩照或荧光素眼底血管造影检查、体格和血液检查,并将结果进行统计分析。结果:4组间的体质指数、收缩压、糖化血红蛋白、空腹血糖、餐后2h血糖、血清甘油三酯、血清高密度脂蛋白、尿微量白蛋白/肌酐比值均有统计学差异(P<0.05);收缩压、糖化血红蛋白、餐后2h血糖、TG、尿微量白蛋白/肌酐比值均与不同分期糖尿病视网膜病变呈正相关关系;高密度脂蛋白与不同分期糖尿病视网膜病变呈负相关关系。结论:收缩压、糖化血红蛋白、餐后2h血糖、血清甘油三酯、血清高密度脂蛋白、糖尿病肾病患病率、尿微量白蛋白/肌酐比值均是糖尿病视网膜病变分期的影响因素,收缩压、糖化血红蛋白和餐后2h血糖、甘油三酯、尿微量白蛋白/肌酐比值越高、高密度脂蛋白越低,糖尿病视网膜病变越严重。

Objective:To explore relationship between different stages of diabetic retinopathy(DR)and blood glucose,blood lipid and other related factors as blood pressure,urine albumin/creatinine ratio(UACR),etc,and to provide scientific basis for study on pathogenesis,prevention and control of DR.Mehods:A total of 196 cases of type 2 diabetes in our hospital were enrolled,and were divided into non-DR group(n=180),non-proliferation DR group(n=11)and proliferation DR group(n=5).Forty normal people were collected as control group.Fundus colorized photography or fundus fluorescence angiography examination,physical and blood tests were performed,and the results were statistically analyzed.Results:BMI,SBP,HbAlc,FPG,P2 hPG,TG,HDL,DN and UACR were significant different among the four groups(P<0.05);SBP,HbAlc,P2 hPG,TG and UACR were positively correlated with different stages of DR;HDL was negatively related with different stages of DR.Conclusions:SBP,HbAlc,P2 hPG,HDL and UACR are influence factors of different stages of DR.The higher SBP,HbAlc,P2 hPG and TG are,the lower HDL is,and the more serious DR is.