| 679 | 15 | 32 |
| 下载次数 | 被引频次 | 阅读次数 |
口腔黏膜炎是恶性肿瘤患者放化疗的常见不良反应,能降低患者生存质量,影响肿瘤治疗方案的进行。肿瘤患者多属本虚标实,受到放疗、化疗的影响后,相火浮越而产生口腔黏膜炎。引火归元法是将浮越的相火导引归于本位,使其恢复生理功能。口腔黏膜炎的治疗不可过用寒凉清热,应在引火归元大法的指导下,辨清证型,从清降心火、补养脾胃、滋补肝肾、温养命门4个方面,导引相火下行。本文为放化疗性口腔黏膜炎的中医治疗提供理论参考。
Abstract:Oral mucositis is a common adverse reaction of radiotherapy and chemotherapy in cancer patients,which reduces the quality of life of patients and affects the progress of cancer treatment. Most of the patients with malignant tumor have the syndrome of deficiency in root case and excess in manifestation. When undergoing radiotherapy or chemotherapy,the patients' ministerial fire becomes hyperactive,which may cause oral mucositis. With the method of"conducting fire back to its origin",ministerial fire can be led to vital gate,as well as recovering its physiological functions. In the treatment of oral mucositis,instead of attacking ministerial fire with too much heat-clearing herbs,we should,under the guidance of the theory of"conducting fire back to its origin",differentiate the syndrome,and then we can use the methods of treatment of clearing and lowering heart fire,warmly invigorating spleen and stomach,nourishing liver and kidney,or warmly invigorating vital gate,to conduct ministerial fire back to vital gate. This article aims to provide a theoretical reference for traditional Chinese medicine treatment of radiotherapy or chemotherapy induced oral mucositis.
1 Choi S,Shin SH,Lee HR,et al.1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol ameliorates chemoradiation-induced oral mucositis[J].Oral Dis,2020,26(1):111-121.
2 Barbosa MM,Araujo AA,Araújo Júnior RF,et al.Telmisartan modulates the oral mucositis induced by 5-fluorouracil in hamsters[J].Front Physiol,2018,9:1204.
3黄湘龙,赵梦瑜,肖璐,等.张伯礼教授“以火立论”辨治口腔溃疡验案分析[J].天津中医药大学学报,2019,38(5):417-419.
4王勇.“引火归元”辨析[J].中国中医基础医学杂志,2011,17(10):1068-1070.
5周胜元,付滨,孟祥震.从《脾胃论》浅析相火[J].云南中医中药杂志,2016,37(6):12-14.
6朱竞明,于智敏,周超凡.中医药治疗肿瘤五要素探析[J].中医杂志,2020,61(6):537-541.
7 Peterson DE,Boers-Doets CB,Bensadoun RJ,et al.Management of oral and gastrointestinal mucosal injury:ESMO clinical practice guidelines for diagnosis,treatment,and follow-up[J].Ann Oncol,2015,26(5):v139-v151.
8杨晨光,许鹏,谢燕华,等.氟尿嘧啶类药物的性味辨析初探[J].医学争鸣,2013,4(4):33-35.
9田雲,杜晓泉,肖尧.基于化疗药物的药效特性论治恶性肿瘤[J].四川中医,2020,38(2):42-45.
10季亚婕,李思雨,吴焕淦,等.化疗对乳腺癌患者中医体质的影响及艾灸的调节作用[J].世界中西医结合杂志,2020,15(4):735-741.
11罗文君,郭栋.交泰丸鼓动肾水治疗老年人复发性口腔溃疡2例验案举隅[J].世界最新医学信息文摘,2018,18(18):158-159.
12赵文明.黄连阿胶汤治疗耳鼻喉疾病的临床应用及理论探析[J].北京中医药,2016,35(12):1156-1157.
13沈雨妍,郑亮.郑亮运用黄连阿胶汤合导赤散治疗口疮临床经验[J].中国民间疗法,2020,28(8):26-27.
14高秀飞,韩淼,胡婵娟,等.补中益气汤加减治疗乳腺癌放化疗期口腔溃疡疗效观察[J].浙江中西医结合杂志,2013,23(3):222-223.
15耿春霞.补中益气汤加减治疗肿瘤化疗后口腔溃疡的临床观察[J].中西医结合研究,2015,7(6):305-306.
16高峻鹰,李庆隆.理中汤加味治疗脾胃虚寒型复发性口腔溃疡疗效及对血清炎性因子和补体C3、C4的影响[J].现代中西医结合杂志,2020,29(9):991-994.
17阮琳洁,王倩,祝捷,等.试论中医“妄火”与肿瘤的发生[J].中医杂志,2019,60(18):1616-1617,1620.
18李自全.引火汤治疗放射性口腔咽部炎症临床观察[J].四川中医,2016,34(9):168-169.
19王曼,周天,胡凯文.引火汤在恶性肿瘤放、化疗不良反应中的应用[J].中医学报,2019,34(6):1156-1158+1187.
20姚晓燕,沈丽霞.六味地黄丸辅助治疗成人复发性口腔溃疡临床研究[J].新中医,2019,51(11):70-72.
21张军梅.金匮肾气丸加味配合中药外敷治疗复发性口腔溃疡临床观察[J].西部中医药,2014,27(9):92-93.
22赵常国,陈艳林,吴生元,等.吴生元经验方加味潜阳封髓丹治疗放化疗后口腔溃疡的临床疗效观察[J].四川中医,2017,35(5):180-182.
23陆金兰,黎淑芳,卢冠铭,等.穴位注射配合穴位外敷治疗乳腺癌化疗后口腔溃疡疗效观察[J].陕西中医,2018,39(4):527-529.
基本信息:
DOI:10.13210/j.cnki.jhmu.20210104.001
中图分类号:R273
引用信息:
[1]陈晨,贾立群.引火归元法在治疗放化疗性口腔黏膜炎中的应用[J].海南医学院学报,2021,27(11):868-871+875.DOI:10.13210/j.cnki.jhmu.20210104.001.
基金信息:
国家自然科学基金面上项目(81973693)~~
2021-01-04
2021-01-04
2021-01-04