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目的:探讨米诺环素联合布洛芬治疗对牙周炎患者龈沟液中炎症因子、碱性磷酸酶(ALP)及一氧化氮(NO)水平的影响。方法:收集来我院就诊的牙周炎患者100例,患牙共计128颗。采用随机数字表法分为对照组与观察组,每组患牙64颗。两组患者均给予常规龈上洁治术及龈下刮治术等基础治疗。对照组给予米诺环素软膏治疗,置于患牙牙周袋内,直至溢出,1次/周;观察组在对照组基础上给予布洛芬治疗,口服2枚/次,2次/天。两组患者均治疗4周。比较两组患牙牙周一般指标;检测两组患者治疗前及疗程结束后,龈沟液中炎症因子、ALP及NO水平。结果:治疗前,两组患者PLI、PD、SBI、AL及龈沟液中TNF-α、CRP、ALP活性及NO水平比较,差异无统计学意义(P>0.05)。治疗后,两组患者PLI、PD、SBI、AL及龈沟液中TNF-α、CRP、ALP活性及NO水平较本组治疗前明显降低,且观察组治疗后PLI、PD、SBI、AL及龈沟液中TNF-α、CRP、ALP活性及NO水平均明显低于对照组治疗后,差异均有统计学意义(P<0.05)。结论:米诺环素联合布洛芬可以通过改善牙周炎患者牙周状况及龈沟液炎症状态,降低ALP活性及NO水平,发挥抗菌及诱导成骨的作用,提高临床疗效。
Abstract：Objective:To investigate the effects of minocycline combined with periocline on patients with periodontitis,and analyze the effect of inflammatory factors,ALP and NO levels in the gingival sulcus fluid.Methods:100 cases of periodontitis in our hospital from May~2017 to December 2016 with a total of 128 teeth were divided into control group and observation group by the random number method,64 teeth in each group.Two groups of patients were given conventional supragingival scaling and subgingival curettage therapy.The control group patients were given minocycline ointment in periodontal pockets until overflow once a week;the observation group were given periocline treatment on the basis of the control group.Oral 2 capsules each time,2 times each day.The two groups were both treated for 4 weeks.The general indicators of 2 groups of teeth was compared.The levels of inflammatory factors,ALP and NO in gingival crevicular fluid of the two groups were detected before and after the treatment.Results:Before treatment,there was no significant difference in the level of PLI、PD、SBI、AL、TNF-α,CRP,ALP and NO in the gingival crevicular fluid of the 2 groups(P>0.05).After treatment,the level of PLI、PD、SBI、AL、TNF-α,CRP,ALP and NO in the gingival crevicular fluid of the 2 groups were significantly lower than those before the treatment,and the level of PLI、PD、SBI、AL,TNF-α,CRP,ALP and NO in gingival crevicular fluid after treatment in the observation group were all significantly lower than that in the control group after treatment,the differences were statistically significant(P<0.05).Conclusion:Minocycline combined with periocline can improve the periodontal condition and gingival crevicular fluid in patients with periodontitis inflammatory state,reduce the activity of ALP and NO levels.It has the effect of antiseptic and induced osteogenesis to improve the clinical effect.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20180403.005
中图分类号:R781.42
引用信息:
[1]袁晓莉,尤再春,文利,等.米诺环素联合布洛芬对牙周炎患者龈沟液中炎症因子、ALP及NO水平的影响[J].海南医学院学报,2018,24(10):1055-1058.DOI:10.13210/j.cnki.jhmu.20180403.005.
基金信息:
重庆市卫生局科研课题(2016-1-126)~~
2018-04-03
2018-04-03
2018-04-03