海南医科大学学报

目的:探讨血清25羟基维生素D浓度与2型糖尿病中代谢参数关系。方法:选取江门市人民医院2014年1月~2015年3月所接诊的80例2型糖尿病患者为观察组,并随机选择同期来江门市人民医院进行体检的80例健康人员为对照组。对两组人员均进行血清25羟基维生素D浓度和代谢参数进行检测,并对血清25羟基维生素D和各项代谢参数之间的关系进行相关性分析。结果:观察组的体重、身高、身体质量指数均显著高于对照组,两组差异具有统计学意义(均P<0.05);两组间低密度脂蛋白胆固醇、钙离子、总胆固醇与对照组比较差异均无统计学意义(均P>0.05);观察组血清25羟基维生素D、高密度脂蛋白胆固醇水平低于对照组(均P<0.05);观察组收缩压、空腹血糖、甘油三酯、舒张压水平均比对照组高,两组比较差异具有统计学意义(均P<0.05);血清25羟基维生素D和与体重、BMI、腹围、收缩压、舒张压、空腹血糖、低密度脂蛋白胆固醇、甘油三酯、糖化血红蛋白呈现负相关。结论:血清25羟基维生素D水平和甘油三酯、低密度脂蛋白胆固醇和糖化血红蛋白有密切的相关性,为以后对2型糖尿病患者的研究可提供参考价值。

Objective:To explore the correlation of serum 25(OH)VitD concentration with the metabolism parameters in patients with type 2diabetes.Methods:A total of 80 patients with type 2diabetes who were admitted in our hospital from January,2014 to March,2015 were included in the study and served as the observation group,while 80 healthy individuals who came our hospital for physical examination were served as the control group.The serum 25(OH)VitD concentration and metabolism parameters in the two groups were detected.The correlation of serum 25(OH)VitD concentration with the metabolism parameters was analyzed.Results:The body weight,height,and BMI in the observation group were significantly higher than those in the control group(P<0.05).The comparison of LDL-C,Ca,and TC between the two groups was not statistically significant(P>0.05).The serum 25(OH)VitD and HDL-C levels in the observation group were significantly lower than those in the control group(P<0.05),while SBP,FBG,TG,and DBP levels were significantly higher than those in the control group(P<0.05).The serum 25(OH)VitD was negatively correlated with body weight,BMI,abdominal circumference,SBP,DBP,FBG,LDL-C,TG,and HbAlc.Conclusions:The serum 25(OH)VitD level is closely associated with TG,LDL-C,and HbAlc,providing a reference value for the study on type 2diabetes.