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目的:探讨脉冲振荡肺功能检查对哮喘儿童病情评估的价值及其与血清指标的相关性。方法:选择哮喘发作期患儿、哮喘缓解期患儿以及健康儿童进行研究,进行脉冲振荡肺功能检查并获取相关参数,采集血清及外周血并检测相关指标。结果:哮喘发作组、哮喘缓解组呼吸总阻抗(Zrs)、总呼吸黏性阻力(R5)、中心气道黏性阻力(R20)、周边气道黏性阻力(R5-R20)、周边弹性阻力(X5)绝对值、共振频率(Fres)均高于对照组(P<0.05),外周血嗜酸性粒细胞、甲壳质酶蛋白40(YKL-40)、Hes-1、富含半胱氨酸蛋白61(Cyr61)、嗜酸粒细胞趋化因子(Eotaxin)、IgE、IgG4、白三烯B4(LT-B4)、LT-C4、LT-D4、半胱氨酸白三烯(Cys-LT)的含量均高于对照组(P<0.05),外周血中Th2、Th17、cTfh、Th19的阳性比例高于对照组(P<0.05),外周血中Th1、Treg阳性比例低于对照组(P<0.05);哮喘发作组患儿上述指标的变化较哮喘缓解组更为显著(P<0.05);Zrs、R5、R20、R5-R20、X5绝对值、Fres与外周血嗜酸性粒细胞、YKL-40、Hes-1、Cyr61、Eotaxin、IgE、IgG4、LT-B4、LT-C4、LT-D4、Cys-LT的含量以及外周血中Th2、Th17、cTfh、Th19的阳性比例呈正相关(P<0.05),与外周血中Th1、Treg阳性比例呈负相关(P<0.05)。结论:脉冲振荡肺功能测定能够为支气管哮喘的诊断以及病情的判断提供依据,脉冲振荡技术(IOS)的相关参数能够判断炎症反应以及免疫反应的异常程度。
Abstract：Objective:To identify value of impulse oscillometry in evaluating the illness in children with asthma and its correlation with serum indicators.Methods:Children with asthma attack,children with asthma remission and healthy children were selected for study.Impulse oscillometry was conducted to obtain related parameters,and serum and peripheral blood were collected to detect related indicators.Results:Zrs,R5,R20,R5-R20,absolute value of X5 and Fres of asthma attack group and asthma remission group were higher than those of control group,eosinophil,YKL-40,Hes-1,Cyr61,Eotaxin,IgE,IgG4,LT-B4,LT-C4,LT-D4 and Cys-LT contents in peripheral blood were higher than those of control group,positive proportion of Th2,Th17,cTfh and Th19 in peripheral blood were higher than those of control group,and positive proportion of Th1 and Treg in peripheral blood were lower than those of control group;the changes of above indicators of asthma attack group were more significant than those of asthma remission group;Zrs,R5,R20,R5-R20,absolute value of X5 and Fres were positively correlated with eosinophil,YKL-40,Hes-1,Cyr61,Eotaxin,IgE,IgG4,LT-B4,LT-C4,LT-D4 and Cys-LT contents in peripheral blood as well as positive proportion of Th2,Th17,cTfh and Th19 in peripheral blood,and negatively correlated with positive proportion of Th1 and Treg in peripheral blood.Conclusions:Impulse oscillometry detection can provide evidence for diagnosis of bronchial asthma and judgment of its illness,and IOS-related parameters can judge the abnormal degree of inflammatory response and immune response.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20160214.003
中图分类号:R725.6
引用信息:
[1]白翠芬.脉冲振荡肺功能检查对哮喘儿童病情评估的价值及与血清指标的相关性分析[J].海南医学院学报,2016,22(10):1016-1019+1023.DOI:10.13210/j.cnki.jhmu.20160214.003.
基金信息:
2015年佛山市医学科研基金项目(2015025)~~
2016-02-14
2016-02-14
2016-02-14