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目的:观察利巴韦林联合酪酸梭菌活菌散临床治疗轮状病毒肠炎患儿,分析患儿血清IL-6、IL-8、TNF-α浓度及T淋巴细胞亚群变化的影响。方法:将收治的90例轮状病毒肠炎患儿随机分为对照组(n=45)和观察组(n=45),其中对照组给予常规治疗联合利巴韦林,观察组在对照组基础上口服酪酸梭菌活菌散治疗。检测所有受试者治疗前后T淋巴细胞亚群和炎性因子指标的变化。结果:治疗前,对照组和观察组血清T淋巴细胞亚群水平均无明显差异(P>0.05)。治疗后,两组血清CD3+、CD4+和CD4+/CD8+水平均高于治疗前本组水平(P<0.05),而CD8+水平低于治疗前;观察组治疗后血清CD3+、CD4+和CD4+/CD8+水平均高于同期对照组,而CD8+水平低于同期对照组,差异有统计学意义(P<0.05)。治疗前,对照组和观察组炎性因子浓度均无明显差异(P>0.05)。治疗后,两组IL-6、IL-8和TNF-α浓度均低于治疗前本组浓度(P<0.05),且治疗后观察组明显低于同期对照组,差异有统计学意义(P<0.05)。结论:在常规治疗和利巴韦林治疗基础上,联合酪酸梭菌活菌散治疗轮状病毒肠炎患儿,能更有效降低患儿外周血炎性因子浓度,降低CD8+T淋巴细胞亚群水平,提高CD3+、CD4+亚群水平,是辅助治疗轮状病毒肠炎患儿潜在有效方案。
Abstract：Objective:To observe the clinical efficacy of ribavirin combined with Clostridium butyricum powder in the treatment of rotavirus enteritis in children,and to analyze the changes of the concentration of serum IL-6,IL-8,TNF-αand T lymphocyte subsets.Methods:A total of 90 patients with rotavirus enteritis were randomly divided into control group(n=45)and observation group(n=45).The control group was given conventional therapy combined with ribavirin while the observation group was treated with Clostridium butyricum powder on the basis of the therapy of control group.The changes of T lymphocyte subsets and inflammatory factors were measured before and after treatment in all subjects.Results:There was no significant difference in serum T lymphocyte subsets between the control group and the observation group before treatment(P>0.05).After treatment,the levels of serum CD3+,CD4+and CD8+in both groups were higher than those before treatment(P<0.05),while CD8+level was lower than that before treatment.The levels of serum CD3+,CD4+and CD8+in the observation group were higher than those in the control group after treatment,while the CD8+level was lower than that of the control group after treatment.The difference was statistically significant(P<0.05).Moreover,There was no significant difference in the concentration of inflammatory factors between the control group and the observation group before treatment(P>0.05).After treatment,the levels of IL-6,IL-8and TNF-αin the two groups were lower than those before treatment(P<0.05).The observation group was significantly lower than the control group after treatment,and the difference was statistically significant(P<0.05).Conclusions:On the basis of routine treatment,ribavirin combined with Clostridium butyricum powder is an effective method for the treatment of rotavirus enteritis in children,which can reduce the concentration of inflammatory factors in peripheral blood,decrease the level of CD8+T lymphocyte subsets and enhance the level of CD3+and CD4+.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20170810.010
中图分类号:R725.1
引用信息:
[1]丁燕苗,李函.利巴韦林联合酪酸梭菌活菌散治疗对轮状病毒肠炎患儿T淋巴细胞亚群和炎性因子的影响[J].海南医学院学报,2017,23(15):2142-2144+2148.DOI:10.13210/j.cnki.jhmu.20170810.010.
基金信息:
南京市医学科技发展专项资金(YKK16121)
2017-08-10
2017-08-10
2017-08-10