海南医科大学学报

目的:观察乌梅丸对溃疡性结肠炎(UC)的临床疗效以及对血清白介素-4(IL-4)和白介素-8(IL-8)水平的影响。方法:将2011年1月～2012年12月本院消化科收治的122例患者按半随机法分为两组,对照组60例采用巴柳氮钠口服治疗,观察组62例加用乌梅丸加减治疗。结果:观察组和对照组治愈率分别为79.03%、36.67%,总有效率分别为95.16%、78.34%,组间比较差异均有统计学意义(P<0.05)。两组治疗后IL-4、双歧杆菌和乳酸菌均升高,IL-8、肿瘤坏死因子-α(TNF-α)和大肠杆菌均降低,与本组治疗前比较,差异均有统计学意义(P<0.01);两组间比较,差异均有统计学意义(P<0.05)。结论:乌梅丸加减联合西药可明显改善UC患者的临床症状,升高IL-4、双歧杆菌和乳酸菌,降低IL-8、TNF-α和大肠杆菌,临床疗效优于单纯使用西药。

Objective:To observe the effects of Wumei Pill on ulcerative colitis and serum IL-4and IL-8levels.Methods:A total of 122cases of ulcerative colitis were randomly divided into 2groups.Sixty patients in control group had balsalazide sodium oral therapy,and 62patients in observation group had Wumei Pill treatment.Results:Cure rates were 79.03%vs.36.67%,the total effective rate were 95.16% vs.78.34%,and the differences were statistically significant between two groups(P<0.05).IL-4, bifidobacteria and lactobacilli were significantly increased in two groups after treatment,IL-8,TNF-αand Escherichia coli were significantly decreased(P<0.01);the differences between groups were statistically significant(P<0.05).Conclusion:Wumei Pill combined with western medicine can alleviate clinical symptoms of patients,elevate UC,IL-4,bifidobacteria and lactic acid bacteria,reduce IL-8,TNF-αand Escherichia coli.The clinical curative effect is better than single western medicine.