海南医科大学学报

目的：评价灵龟八法针刺疗法治疗失眠的疗效和安全性，以更好服务临床，为失眠的治疗提供参考思路。方法：检索CNKI,CBM，万方，维普，中国临床试验注册中心数据库中使用灵龟八法对比其他干预方案治疗失眠的文献，检索期限为建库至2021年8月1日，由2名研究员对文献进行独立的质量评价和效应量提取，使用STATA16.0和Review5.3对文献进行Meta分析和质量评价。通过筛选，共有18篇符合条件的文献参与Meta分析，共1 583例病例。结果：（1）灵龟八法治疗失眠疗效的有效率较对照组高[RR=1.213,95%C(I1.155,1.274),Z=7.71,P<0.01];(2)灵龟八法治疗失眠的匹兹堡睡眠质量指数（PSQI）较其他针刺疗法治疗后评分更低[WMD=-2.33,95%C(I-2.75，-1.91),Z=10.97,P<0.01];(3)灵龟八法治疗失眠治疗后随访1个月PSQI评分较对照组治疗后评分更低[WMD=-3.263,95%CI（-3.446，-3.080）,Z=34.96,P<0.01];(4)没有研究报告在治疗组和对照组治疗中发生严重不良反应。结论：基于目前研究，灵龟八法治疗失眠效果优于对照组，适合临床推广应用，但仍需更多高质量的临床研究证明其疗效可靠。

Objective: To systematically evaluate the efficacy and safety of the spirit turtle eight method acupuncture therapy in the treatment of insomnia, to better serve the clinic and provide reference ideas for the treatment of insomnia. Methods: Search CNKI, CBM, Wanfang, Weipu, China Clinical Trial Registry databases on the use of the spirit turtle eight method com-pared with others interventions to treat insomnia. The search period is from the library until August 1, 2021, two researchers will conduct independent quality evaluation and effect size extraction on the literature, and use STATA16.0 and Review5.3 to conduct Meta analysis and quality evaluation on the literature. Through screening, a total of 18 eligible documents participated in the meta-analysis, with a total of 1583 cases. Results:(1)The effective rate of the spirit turtle eight method in the treatment of insomnia is higher than the control group[ RR=1.213, 95%C(I1.155, 1.274), Z=7.71, P<0.01];(2)The Pittsburgh Sleep Quality Index( PSQI) score is lower than other acupuncture treatments[ WMD=-2.33, 95%C(I-2.75,-1.91), Z=10.97, P< 0.01];(3)The one-month follow-up PSQI score after the treatment of insomnia by the spirit turtle eight method is lower than the control group[ WMD=-3.263, 95%CI（-3.446,-3.080）, Z=34.96, P<0.01];(4) No studies have reported serious adverse reactions in the treatment group and control group. Conclusion: Based on the current research, the spirit turtle eight method are better than the control group in the treatment of insomnia, and are suitable for clinical application. However, more high-quality clinical studies are still needed to prove its efficacy.