海南医科大学学报

目的:探讨轮状病毒性(RV)肠炎患儿肝功能及心肌酶谱变化及其临床意义。方法:选取本收治的RV肠炎患儿70例设为观察组,检测入选患儿治疗前后肝功能及心肌酶谱变化,统计肝脏、心肌损伤RV肠炎患儿比率;分析脱水对RV肠炎患儿肝功能及心肌酶谱的影响。并设同期收治的非RV肠炎患儿65例为对照组,进行对比观察。结果:观察组患儿血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)及α-羟丁酸脱氢酶(α-HBDH)水平及肝脏、心肌损伤患儿比率均显著高于对照组(P<0.05);观察组患儿血清ALT、AST、CK、CK-MB、LDH及α-HBDH水平随脱水程度加重而呈升高趋势(P<0.05);观察组中肝脏、心肌损害患儿共45例,治疗后其ALT、AST、CK、CK-MB、LDH及α-HBDH水平较治疗前显著降低(P<0.05)。结论:早期进行肝功能及心肌酶谱检测能准确反应RV肠炎患儿病情,为临床治疗方案制订提供依据。

Objective:To explore the changes and clinical significance of liver function and myocardial zymogram in children with rotavirus(RV)enteritis.Methods:A total of 70 children with RV enteritis who were admitted in our hospital were included in the study and served as the observation group.The liver function and myocardial zymogram before and after treatment were detected.The proportion of RV enteritis children with liver and myocardial damage was calculated.The effect of dehydration on the liver function and myocardial zymogram in children with RV enteritis was analyzed.A total of 65 children with non-RV enteritis who were admitted in our hospital at the same stage were served as the control group.Results:The serum ALT,AST,CK,CK-MB,LDH,andα-HBDH levels,and liver myocardial damage children proportion in the observation group were significantly higher than those in the control group(P<0.05).The serum ALT,AST,CK,CK-MB,LDH,andα-HBDH levels in the observation group were significantly elevated with the acceleration of dehydration degree(P<0.05).In the observation group,45 children had liver and myocardial damage,whose ALT,AST,CK,CK-MB,LDH,andα-HBDHlevels after treatment were significantly reduced when compared with before treatment(P<0.05).Conclusions:Early detection of liver function and myocardial zymogram can accurately reflect the condition in children with RV enteritis,which can provide an evidence for the formulation of clinical treatment protocol.