海南医科大学学报

目的:观察分析布地奈德氧气雾化吸入对慢阻肺急性发作期患者的影响,以了解其在改善患者胸肺顺应性及气体交换方面的作用。方法:选取2011年11月～2013年2月于本院进行常规治疗的41例慢阻肺急性发作期患者为对照组,并选取同期在常规治疗基础上加用布地奈德氧气雾化吸入治疗的41例患者为观察组,然后将两组患者治疗前与治疗后3d、5d的胸肺顺应性、肺通气及呼吸参数进行比较。结果:观察组治疗后3d、5d的胸肺顺应性、肺通气及呼吸参数改善幅度均大于对照组,并且观察组治疗后3d与5d的均好于治疗前,P均<0.05,均有显著性差异。结论:布地奈德氧气雾化吸入可有效改善慢阻肺急性发作期患者呼吸应答,因此对患者的低氧状态发挥出积极的改善作用。

Objective: To observe and analyze the influence of budesonide inhalation by oxygen atomizing to lung and thorax compliance and air exchange indexes of patients at acute stage of COPD.Methods:A total of 41 patients at acute stage of COPD that were treated with conventional therapy in our hospital from November 2011 to February 2013 were selected as control group,41 patients treated with conventional therapy and budesonide inhalation by oxygen atomizing were selected as observation group,then the thorax compliance,pulmonary ventilation and respiratory parameters of two groups before the treatment and 3 and 5 days after treatment were compared.Results:The improvement of thorax compliance,pulmonary ventilation and respiratory parameters of observation group 3 and 5 days after treatment were significant better than that before the treatment(P<0.05).Conclusion:The budesonide inhalation by oxygen atomizing can effectively improve the respiratory response of patients at acute stage of COPD,so it plays an active role in improving the hypoxia state and patients.