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目的:探讨鲑鱼降钙素治疗骨质疏松症的疗效及对患者骨代谢标志物水平的影响。方法:在我院接受治疗的骨质疏松症患者140例,随机分成对照组和观察组,两组各70例。对照组口服骨化三醇软胶囊以及维D钙咀嚼片治疗,观察组接受对照组治疗的同时应用鲑鱼降钙素治疗。结果:观察组患者总有效率为85.71%,高于对照组患者总有效率(70.00%),差异具有统计学意义(P<0.05)。治疗后,观察组患者的粗隆(Torch)、股骨颈(Neck)、腰椎L14以及Ward氏三角区(Ward's)区域的骨密度高于对照组患者,差异具有统计学意义(P<0.01)。治疗后,观察组患者的骨代谢相关指标β-胶原片段(β-CTX)、骨钙素(N-MID)、碱性磷酸酶(ALP)水平低于对照组,且观察组患者降钙素(hCT)水平高于对照组,差异具有统计学意义(P<0.01)。结论:鲑鱼降钙素治疗骨质疏松症疗效显著,能够有效改善缓解患者的症状,提高骨密度、改善骨代谢。
Abstract：Objective:To study the effect of osteoporosis calcitonin salmon on the level of bone metabolism markers in patients with osteoporosis.Methods:A total of 140 cases with osteoporosis were were randomly divided into control group and observation group,with 70 cases in each.Patients in control group were treated with calcitriol soft capsules and chewable calcium vitamin D.Patients in observation group were treated with salmon calcitonin.Results:The total efficiency of the observation group patients was 85.71%,significantly higher than 70.00%that of control group(P<0.05).After treatment,BMD of Torch,Neck,L1-L4 and Ward's area in observation group patients were significantly higher than that of control group(P<0.01).After treatment,bone metabolism related indicatorsβ-CTX,N-MID,ALP level in observation group patients were significantly lower than that of control group,and hCT level in observation group patients was significantly higher than that of control group(P<0.01).Conclusions:Salmon calcitonin is effective in treatment of osteoporosis.It can effectively relieve the symptoms,increase bone density and improve bone metabolism.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20150226.010
中图分类号:R580
引用信息:
[1]樊险峰,黄兴华,黄运咏,等.鲑鱼降钙素治疗骨质疏松症的疗效及对骨代谢标志物水平的影响[J].海南医学院学报,2015,21(08):1137-1139.DOI:10.13210/j.cnki.jhmu.20150226.010.
基金信息:
四川省科技厅科研课题(2013ZR00911)~~
2015-02-26
2015-02-26
2015-02-26