海南医科大学学报

目的:探讨阿维A联合窄谱中波紫外线(NB-UVB)治疗寻常型银屑病的临床疗效。方法:选取我科2014年6月~2015年6月收治的50例寻常型银屑病患者作为研究对象,随机分为观察组(阿维A联合NB-UVB)和对照组(阿维A);对照组采用阿维A 10mg/次,2次/d于餐后口服;观察组在对照组的基础上联合NB-UVB进行照射治疗,时间30min/次,每周3次;两组疗程均为8周,并观察两组银屑病面积严重度指数(PASI)评分、临床治疗效果及临床症状评分。结果:随着治疗周期的延长PASI指数逐渐减低,观察组治疗2、4、8周后PASI指数明显低于对照组,两组比较,差异有统计学意义(P<0.05);治疗8周后观察组总有效率为96.00%,明显高于对照组(76.00%),差异有统计学意义(P<0.05);观察组治疗8周后红斑、瘙痒、鳞屑、浸润症状改善显著优于对照组,差异有统计学意义(P<0.05)。结论:阿维A联合NB-UVB对寻常型银屑病有协同治疗作用,可显著改善临床症状,提高临床疗效,值得进一步推广。

Objective:To explore the clinical efficacy of acitretin in combined with narrow band ultraviolet B(NB-UVB)in the treatment of psoriasis vulgaris.Methods:A total of 50 patients with psoriasis vulgaris who were admitted in our hospital from June,2014 to June,2015 were included in the study and randomized into the observation group and the control group.The patients in the control group were given acitretin,10mg/time,P.O.after dinner,twice a day.On this basis,the patients in the observation group were given additional NB-UVB for irradiation therapy,30 min a time,three times a week.Eight-week treatment was regarded as one course.PASI scores,the clinical treatment efficacy,and the clinical symptoms in the two groups were observed.Results:With the extending of treatment cycle,PASI was gradually reduced.2,4,and 8weeks after treatment PASI scores in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate was 96.00% after 8-week treatment in the observation group and was significantly superior to that in the control group with 76.00%(P<0.05).The improvements of erythema,pruritus,scales,and infiltration after 8-week treatment in the observation group were significantly superior to those in the control group(P<0.05).Conclusions:Acitretin in combined with NB-UVB in the treatment of psoriasis vulgaris can produce a synergistic effect,significantly improve the clinical symptoms,and enhance the clinical efficacy;therefore,it can be further recommended.