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目的:通过综合荟萃分析,调查午睡是否与患高血压风险增加有关。方法:文献检索、研究选择、资料提取等独立进行,效应大小估计用风险比(RR)和95%置信区间(CI)表示。结果:13篇文章中涉及119 501名成年人的摘要数据纳入Meta分析。总体分析显示,在纳入的样本量中,未调整因素时,午睡与高血压风险有显著相关性(RR=1.11,95%CI:1.02～1.21,P=0.013),调整可能的混杂因素后,午睡与高血压风险仍然具有相关性(RR=1.07,95%CI:1.01～1.14,P=0.041)。在亚组分析中,有午睡习惯的女性(RR=1.13,95%CI:1.04～1.22,P=0.004)与高血压之间有明显的相关性,而在男性人群中未发现此种联系;≥45岁的人群(RR=1.16,95%CI:1.08～1.24,P<0.001)其午睡与高血压有显著的相关性。在剂量分析中发现午睡时长≥90 min的人群(RR=1.13,95%CI:1.01～1.27,P=0.04)与高血压之间有明显的相关性。结论:午睡是患高血压的风险因素,这种联系在女性人群中更为明显,差异有统计学意义;在≥60岁的老年人群中,午睡为高血压的保护因素。
Abstract：Objective: To investigate whether nap is associated with an increased risk of hypertension through a comprehensive meta-analysis. Methods: Literature retrieval, research selection and data extraction were done independently and in duplicate. Effect-size estimates are expressed as risk ratio(RR) and 95% confidence interval(CI). Results: Summary data from 13 articles, involving a total of 119 501 adults, were meta-analyzed. The overall analysis showed that in the included articles, when the factors were not adjusted, there was a significant association between nap and hypertension(RR=1.11, 95% CI:1.02 to 1.21, P=0.013). After adjusting the possible confounding factors, nap was still correlated with hypertension(RR=1.07, 95% CI: 1.01 to 1.14,P=0.041). In the subgroup analysis, there was a significant association between nap and hypertension in women(RR=1.13, 95% CI: 1.04 to 1.22,P=0.004), but this relationship was not recurred in men. And there was a significant association between nap and hypertension in people ≥ 45 years old(RR=1.16, 95% CI:1.08 to 1.24, P<0.001). In the dose analysis, it was found that there was a significant association between high blood pressure and the population with nap duration ≥ 90 min(RR=1.13, 95% CI: 1.01 to 1.27,P=0.04).Conclusion:Nap is a risk factor for hypertension, which is more obvious in women, and the difference is statistically significant. In the elderly people ≥ 60 years, nap is a protective factor for hypertension.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20200410.005
中图分类号:R544.1
引用信息:
[1]何梦阳,杨瑶,郭一霆,等.午睡与高血压关系的Meta分析[J].海南医学院学报,2020,26(15):1167-1172.DOI:10.13210/j.cnki.jhmu.20200410.005.
基金信息:
人事部留学归国人员创新项目(2015192)~~
2020-04-10
2020-04-10
2020-04-10