海南医科大学学报

目的:分析注射用丹参多酚酸盐对脑梗死患者相关血液指标的影响。方法:选取2013年10月~2014年10月我院收治的84例脑梗死患者作为研究对象,均为脑血栓形成型脑梗死,采用数字表法分为常规治疗组和观察组,每组42例。常规治疗组根据患者的分期及个体实际情况采用个体化治疗,给予营养、消除脑水肿、溶栓治疗,观察组患者在常规治疗基础上加用注射用丹参多酚酸盐治疗。观察并比较两组患者治疗前后的内皮素-1(ET-1)、凝血酶调节蛋白(TM)、血小板计数、血栓素B2(TXB2)、前列环素化时产物(6-酮-PGF1α)、抗凝血酶-Ⅲ(AT-Ⅲ)、蛋白C、蛋白S、凝血时间、活化部分凝血活酶时间(APTT)、组织型纤溶酶原活化因子(t-PA)、纤溶酶原激活物抑制剂(PAI)、血浆黏度(ηb)的变化。结果:两组患者经2周治疗后,ET-1、TM、血小板计数、TXB2、PAI-1、ηb、全血黏度均降低,与治疗前比较差异均有统计学意义(P<0.05);而6-酮-PGF1α、凝血时间、APTT、抗凝血酶-Ⅲ、蛋白C、蛋白S、血浆t-PA均升高,与治疗前比较差异均有统计学意义(P<0.05),且治疗后,观察组患者ET-1、TM、TXB2、ηb均明显低于常规治疗组,组间比较差异有统计学意义(P<0.05),6-酮-PGF1α、抗凝血酶-Ⅲ、蛋白C、t-PA明显高于常规治疗组,组间差异有统计学意义(P<0.05)。结论:注射用丹参多酚酸盐辅助治疗血栓形成型脑梗死患者,能提高患者血栓相关指标的改善效果,对患者后续恢复具有积极意义。

Objective:To investigate effects of salvianolate injection on serum indexes of patients with cerebral infarction.Methods:A total of 84 patients with cerebral infarction that were caused by cerebral thrombosis treated in our hospital from October 2013 to October 2014 were selected and randomly divided into control group and study group(n=42).Patients in control group were given individualized treatment,like nutrition,encephaledema elimination,thrombolytic treatment,according to their disease staging and personal situation.Based on individualized treatment that was given to the control group,patients in study group were given salvianolate injection treatment.Endothelin-1(ET-1),thrombomodulin(TM),blood platelet count,TXB2,6-ketone-PGF1α,antithrombin-Ⅲ(AT-Ⅲ),protein C,protein S,coagulation time,APTT、fibrinolysis activity:plasminogen,activity loss:t-PA and PAI,plasma viscosity(ηb)were detected and compared between the two groups.Results:2weeks after treatment,ET-1,TM,blood platelet count,TXB2,PAI-1,ηb,whole blood viscosity in both groups were significantly decreased(P<0.05);while 6-ketone-PGF1α,coagulation time,APTT,antithrombin-Ⅲ,protein C,protein S,plasma t-PA in both groups were increased significantly(P<0.05).After treatment,ET-1,TM,TXB2,ηb in study group were significant lower than that in control group(P<0.05).6-ketone-PGF1α,antithrombin-Ⅲ,protein C,t-PA in study group were significantly higher than that in control group(P<0.05).Conclusion:For patients with thrombosis cerebral infarction,Salvianolate injection adjuvant therapy could improve the related indexes of thrombus which is favorable for patients' recovery.