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目的:分析小剂量多巴胺联合多巴酚丁胺辅助治疗对重症肺炎患儿炎症因子水平的影响及其与预后情况的相关性。方法:选择在本院接受住院治疗的86例重症肺炎患儿作为研究对象,随机分为接受常规治疗的对照组及接受小剂量多巴胺联合多巴酚丁胺辅助治疗的观察组,比较两组患儿的血清学指标、临床症状改善时间。结果:(1)炎症因子:观察组患儿的白介素-8(IL-8)、C反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)含量低于对照组(P<0.05);(2)免疫分子:观察组患儿外周血中TLR4、核转录因子(NF-κB)和MyD88含量低于对照组(P<0.05);(3)基质金属蛋白酶(MMP)功能:观察组患儿的MMP9含量以及MMP9/金属蛋白酶组织抑制剂1(TIMP1)比例低于对照组,TIMP1含量高于对照组(P<0.05);(4)IL-8、CRP、TNF-α、TLR4、NF-κB、MyD88、MMP9、TIMP1含量以及MMP9/TIMP1比例与临床症状改善时间呈正相关,TIMP1含量与临床症状改善时间呈负相关。结论:小剂量多巴胺联合多巴酚丁胺辅助治疗有助于降低血清炎症因子、免疫分子含量,降低MMP分子的损伤作用,且与临床症状改善情况密切相关。
Abstract：Objective:To explore the effect of low-dose dopamine combined with dobutamine on inflammatory cytokines levels and prognosis of children with severe pneumonia.Methods:A total of 86 children with severe pneumonia in our hospital were selected as research object,and were randomly divided into control group with conventional treatment and observation group with low-dose dopamine combined with dobutamine therapy.Then serum index and time of improvement in clinical symptoms were compared.Results:IL-8,CRP and TNF-αcontents of observation group were lower than those of control group.TLR4,NF-kB,MyD88 contents of observation group were lower than those of control group.MMP9 content and MMP9/TIMP1 ratio of observation group were lower than those of control group;TIMP1content was higher than that of control group.Conclusions:Small dose dopamine combined with dobutamine therapy can reduce serum inflammation factor and immune molecule content,decrease MMP's injury effect and is closely correlated with improvement of clinical symptoms.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20150108.007
中图分类号:R725.6
引用信息:
[1]白海波.小剂量多巴胺联合多巴酚丁胺辅助治疗对重症肺炎患儿血清学指标的影响及其与预后的关系[J].海南医学院学报,2015,21(05):695-698.DOI:10.13210/j.cnki.jhmu.20150108.007.
基金信息:
云浮市医学科学技术研究项目(2011B031)~~
2015-01-08
2015-01-08
2015-01-08