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目的：饮食习惯已被证实会对自身免疫性疾病产生影响，然而奶酪摄入是否与自身性免疫病有关仍不明确。方法：本研究利用全基因组关联研究（GWAS）数据，数据来源于UK Biobank数据库，通过双样本孟德尔随机化（MR）分析，探讨奶酪摄入与自身免疫性疾病之间的潜在因果关系。本研究严格筛选单核苷酸多态性（SNP）作为工具变量（IV），并采用逆方差加权（IVW）、MR-Egger、加权中值、简单模式及加权模式等方法进行MR分析。敏感性分析方法包括异质性测试、水平多效性测试、逐一剔除分析法及MR-PRESSO分析，确保研究结论的可靠性。结果：本研究纳入了13种自身免疫性疾病（如干燥综合征、幼年类风湿关节炎、溃疡性结肠炎、1型糖尿病、系统性硬化症、重症肌无力、类风湿关节炎、系统性红斑狼疮、局限性硬皮病、多发性硬化、自身免疫性甲状腺炎、炎症性肠病及乳糜泻）。IVW分析结果显示，奶酪摄入仅对溃疡性结肠炎（P=0.017,OR=0.997,95%CI=0.994～0.999）、类风湿关节炎（P=0.001,OR=0.993,95%CI=0.990～0.997）及局限性硬皮病（P=0.009,OR=12.936,95%CI=1.904～87.894）有影响。此外，研究还显示低脂硬质奶酪可能加重类风湿关节炎（P=0.022,OR=1.001,95%CI=1.0001～1.002）。结论：高奶酪摄入可能降低溃疡性结肠炎和类风湿关节炎的患病风险，但显著增加局限性硬皮病的患病风险。
Abstract：Objective: To investigate whether cheese intake associated with autoimmune diseases since dietary habits have been confirmed to affect autoimmune diseases. Methods: We obtained genome-wide association study data from the UK Biobank.Two-sample MR analyses were used to explore the potential causal role of cheese intake in autoimmune diseases outcome. In order to reveal the causal relationship between cheese intake and autoimmune diseases, single nucleotide polymorphisms were rigorously selected as instrumental variables. MR analysis was performed using the inverse variance weighted, MR-Egger, weighted median, simple mode and weighted mode methods. To ensure the reliability of the conclusions, sensitivity analyses were indispensable and included heterogeneity testing, horizontal pleiotropy testing, leave-one-out analysis, and MR-PRESSO analysis. Results: Thirteen autoimmune diseases were included in the analysis, such as Sjogren's syndrome, Juvenile rheumatoid arthritis, ulcerative colitis, Type 1 diabetes, systemic sclerosis, Myasthenia gravis, Rheumatoid arthritis, Systemic lupus erythematosus, Localized scleroderma, Multiple sclerosis, Autoimmune thyroiditis, Inflammatory bowel disease and Celiac disease. In terms of the exposure factor for cheese intake, the inverse variance weighted(IVW) showed that only three autoimmune diseases are affected by cheese intake, and the P value and odds ratio are as follows: ulcerative colitis(P=0.017, OR=0.997, 95%CI=0.994-0.999), Rheumatoid arthritis(P=0.001, OR=0.993, 95%CI=0.990-0.997), Localized scleroderma(P=0.009, OR=12.936, 95%CI=1.904-87.894). Furthermore, this study shows that low-fat hard cheeses can aggravate rheumatoid arthritis(P=0.022, OR =1.001, 95%CI=1.000 1-1.002). Conclusion: A high intake of cheese intake may be associated with a decreased risk for ulcerative colitis and rheumatoid arthritis, but with a substantial increase in risk for localized scleroderma.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20250325.003
中图分类号:R593.2
引用信息:
[1]吴志杰,傅祥炜,张黎,等.奶酪摄入与自身免疫性疾病的因果关系：一项两样本孟德尔随机化研究[J].海南医科大学学报,2025,31(08):608-616.DOI:10.13210/j.cnki.jhmu.20250325.003.
基金信息:
海南省财政科技计划资助项目（ZDYF2023SHFZ095）~~
2025-03-26
2025-03-26
2025-03-26