| 26 | 0 | 5 |
| 下载次数 | 被引频次 | 阅读次数 |
Objective: To assess the prevalence of cervical cancer and histologic variants as seen in Calabar,Cross River state.Methods: This is a retrospective study involving histologically verified uterine cervix carcinoma between January,1997 and December,2006.Results: There were 1,207 malignancies diagnosed during the study period;175(14.5%) were malignancies of the genital tract while 113(9.4.0%) were carcinoma of the cervix constituting 64.6% of female genital malignancies.Cervical cancer was commonest between the ages of 40-59 years.There was no patient with carcinoma of the cervix below the age of 20 years.Squamous cell carcinoma(87.6%) of the uterine cervix was the main histological type.Conclusion:Cervical cancer is still the most common female genital tract malignancy in Calabar with most of these patients in their middle age.The use of PAS/Alcian blue stain as was used in this study eliminates most false-positive squamous cell carcinomas compared with Haematoxylin and Eosin stains used in most reports from most centres in this part of the world.Epithelial malignancies continue to be the predominant histological variant with squamous cell variety the commonest.There is also an urgent need for introduction of efficient and affordable population based cervical screening programme for early detection,use of vaccines against Human Papilloma Virus(HPV) and treatment of pre-malignant cervical lesions.
Abstract：Objective: To assess the prevalence of cervical cancer and histologic variants as seen in Calabar,Cross River state.Methods: This is a retrospective study involving histologically verified uterine cervix carcinoma between January,1997 and December,2006.Results: There were 1,207 malignancies diagnosed during the study period;175(14.5%) were malignancies of the genital tract while 113(9.4.0%) were carcinoma of the cervix constituting 64.6% of female genital malignancies.Cervical cancer was commonest between the ages of 40-59 years.There was no patient with carcinoma of the cervix below the age of 20 years.Squamous cell carcinoma(87.6%) of the uterine cervix was the main histological type.Conclusion:Cervical cancer is still the most common female genital tract malignancy in Calabar with most of these patients in their middle age.The use of PAS/Alcian blue stain as was used in this study eliminates most false-positive squamous cell carcinomas compared with Haematoxylin and Eosin stains used in most reports from most centres in this part of the world.Epithelial malignancies continue to be the predominant histological variant with squamous cell variety the commonest.There is also an urgent need for introduction of efficient and affordable population based cervical screening programme for early detection,use of vaccines against Human Papilloma Virus(HPV) and treatment of pre-malignant cervical lesions.
1 Schoell WM,Janicek MF,Mirhacheni R.Epidemiologyand biology of cervical cancer.Sem Surg Oncol1999;16:203-211.
2 Asuien MI,Ahmani mugan S.Reviewof cervical cancerat the University of Benin Teaching Hospital,Benin cit-y.In:Obstetrics and gynaecology in developing coun-tries.Proceedings of an International Conference.Ni-geria:Society of Obstetricians and Gynaecologists of Ni-geria;1997.
3 Edozien LC,Adewole IF.Cervical cancer in Nigeria-aneedfor early detection.Afr J Med med Sci1993:22;87-92.
4 Babarinsa IA,Akang EEU,Adewole IF.Pattern ofgynaecological malignancies at the Ibadan cancer regis-try(1976-1995).Nigerian.QuarterlyJournal of Med-icine1998;8:103-106.
5 Bosch FX,Munoz N,de Sanjose S.Human papillomavirus and other risk factors for cervical cancer.BiomedPharmacother1997;51:268-275.
6 Ekanem E,Abidoye R.Some epidemiologic and clinicalfeatures of cervical cancer in Lagos,Nigeria.PublicHealth1987;101:123-128.
7 Emembolu JO,Ekwempu CC.Carcinoma of the cervixuteri in Zaria:epidemiological factors.Int J Obstet Gy-necol1998;26:265-269.
8 Nnatu SN,Durosinmi-Etti FA.The problems withthemanagement of carcinoma of the cervix in Nigeria-La-gos experience.East Afr Med J1985;62:347-354.
9 Omigbodun AO,Akanmu TI.Clinicopathologic corre-lates of disease stages in Nigerian cervical cancer pa-tients.J Obstet Gynaecol East Cent Afr1991;9:79-81.
10 Ayinde OA,Omigbodun AO.Knowledge,attitude andpractices related to prevention of cancer of the cervix a-mong female health workersinIbadan.J Obstet Gynecol2003;23:55-58.
11 Dubois G.Cytological screening for cervix cancer:eachyear or three years?Eur J Obstet Gynecol Reprod Biol1996;65:57-59.
12 Sawayua GF,Brown AD,Washington AE,GarberAM.Current approaches to cervical cancer screening.NEngl J Med2001;344:1603-1607.
13 EkanemIA,Ekpo MD,Perera PAC,Khalil MI,AttahEd'B.Female genital malignancyin south-east Nigeri-a:aten year histological analysis withemphasis oncervi-cal cancer.In women's health issues in Nigeria.Zaria:Tamaza publishing companyli mited;1999;2:39-46.
14 Nwosu SO,Enya SE.Malignancies of the female genitaltract at the University of Port Harcourt Teaching Hospi-tal.A ten year review(1990-1999).The Nig Med2004;11(2):107-109.
15 Nkyekyer K.Pattern of gynaecological cancers in Gha-na.East Afr Med J2000;77:12-16.
16 Pindiga UH,EL-Nafarty AU,EkanemIA.Female gen-ital malignancies in Maiduguri,Nigeria:Areviewof ca-ses.TropJ Obstet Gynecol1999;(16):52-56.
17 Briggs ND,Katchy KC.Pattern of pri mary gynaecologi-cal malignanciesin a tertiary hospital situatedinthe Riv-ers state of Nigeria.Int J Gynecol Obstet1999;31:157-161.
18 Reis LAG,kosary CL,Hankey BF,Eisner MP,MillerBA.SEERCancer Statistic Review,1973-1996.Nation-al Cancer Institute;1999.
19 Emem AB,Ekpo MD,Abasiatai A.Female genital tractmalignancies in Uyo,south-south Nigeria.The NigMed2007;2:134-136.
20 Abdul MA,Mohammed A,Mayun A,Shittu SO.Non-Squamous Cell Carcinoma of the Cervixin Zaria,North-ern Nigeria:A Clinico-Pathological Analysis,Annals ofAfrican Medicine2006;5(3):118-121.
21 Omoniyi-Esan DG,Fasuba OB,Adelusola KA,Ojo OS.Histological pattern of cervical malignancies in South-western Nigeria.TropJ Obstet Gynaecol2004;21(2):181-121.
22 Buckley CH,Fox H.carcinoma of the cervix.Recentadvances in Histopathology1989;14:63-78.
23 Tambouret R,Bell DA,Young RH.Microcystic endo-cervical adenocarcinomas:a report of eight cases.AmJSurg Patholo2000;24:369-374.
24 Peto J,GilhamC,Fletcher O,Matthews FE.The cer-vical cancer epidemic that screening has preventedin theUK.Lancet2004;364:249-256.
25 Murat D,Güzin D,Salih D,Mufit CY,Umit G.Vil-loglandular Papillary Adenocarcinoma of the UterineCervixina Pregnant Woman:ACase Report and Reviewof Literature.The Tohoku Journal of ExperimentalMedicine2004;202(4):305-310.
26 Grayson W,Cooper K.Areappraisal of"Basaloid carci-noma"of the cervix,and the differential diagnosis ofbasaloidcervical neoplasms.Adv Anat Patholo2002;9:290-300.
27 Brinck U,Jakob C,Bau O,Fuzesi L.Papillary squa-mous cell carcinoma of the uterine cervix:report of threecases and a review of its classification.Int J GynecolPathol2000;19:231-235.
28 Abeler VM,Hol mR,NeslandJ M,Kjorstad KE.Smallcell carcinoma of the cervix.Aclinicopathologic study of26 patients.Cancer1994;73:672-677.
29 Silva EG,Gershenson D,Sncige N,Brock WA,SandP,Capeland LJ.Small cell carcinoma of the uterine cer-vix:Pathology and prognostic factors Surg.Pathol1989;2:105.
30 Cui S,Lespinasse P,Cracchiolo B,Sama J,KreitzerMS,Heller DS.Large Cell neuroendocrine carcinoma ofthe cervix association with adenocarcinoma in-situ:evi-dence of a common origin.Int J Gynecol Pathol2001;20:311-312.
基本信息:
DOI：10.13210/j.cnki.jhmu.2010.01.034
中图分类号:R737.33
引用信息:
[1]Omotoso AJ,Agan TU,Bassey IE,等.Cervical cancer in Calabar,Nigeria[J].海南医学院学报,2010,16(01):28-32.DOI:10.13210/j.cnki.jhmu.2010.01.034.
2010-01-28
2010-01-28