nav emailalert searchbtn searchbox tablepage yinyongbenwen piczone journalimg journalInfo journalinfonormal searchdiv searchzone qikanlogo popupnotification paper paperNew
2022, 07, v.28 481-485
新冠病毒变异株“奥密克戎”的最新研究进展
基金项目(Foundation): 第九四〇医院新冠肺炎应急医学科研项目(20yjky020); 火神山医院科研基金面上项目(HSS-217)~~
邮箱(Email): zhangjiucong@163.com;
DOI: 10.13210/j.cnki.jhmu.20220128.001
摘要:

新型冠状病毒肺炎(COVID-19)是由新型冠状病毒(SARS-CoV-2)引起的一种具有发病率、致死率极高的新型呼吸系统传染病。由于SARS-CoV-2本身的特异性,其突变率较高,目前已出现一系列不同的SARS-CoV-2变异株,使COVID-19疫情一直反复。近日,世界卫生组织(WHO)公布了新变异株“奥密克戎”(Omicron,B.1.1.529),并宣称该变异株可能具有较强的传染性、较高的抗体耐受性及疫苗耐受性。本文就“奥密克戎”变异株的最新研究进展作一简要综述。

Abstract:

Coronavirus disease 2019(COVID-19)is a novel respiratory infectious disease with high incidence and mortality rate caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). Due to the specificity of the novel coronavirus SARS-CoV-2 itself and its high mutation rate,a series of different novel coronavirus variants have appeared,which has led to repeated outbreaks of COVID-19. Recently,the World Health Organization(WHO)has announced a new variant "Omicron"(Omicron,B.1.1.529),and declared that the mutant strain may be highly infectious,antibody tolerant and highly resistant to vaccines. This article briefly reviews the latest research progress of the "Omicron" variants.

参考文献

1姚晓文,周玉霞,王蓉,等.2019新型冠状病毒变异株的研究进展[J].中华传染病杂志,2022,40(2):111-115.

2 Wang W,Tang J,Wei F.Updated understanding of the outbreak of 2019 novel coronavirus(2019-n Co V)in Wuhan,China[J].J Med Virol,2020,92(4):441-447.

3 Weiss SR,Navas-Martin S.Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus[J].Microbiol Mol Biol Rev,2005,69(4):635-664.

4符婷,黄丽菊,杨进军,等.55例新型冠状病毒肺炎流行病学特征及重症影响因素[J].中华医院感染学杂志,2020,30(17):2575-2578.

5 Wu F,Zhao S,Yu B,et al.A new coronavirus associated with human respiratory disease in China.Nature[J].2020,579(7798):265-269.

6 Su S,Wong G,Shi W,et al.Epidemiology,genetic recombination,and pathogenesis of coronaviruses[J].Trends Microbiol,2016,24(6):490-502.

7王玉燕.棘突蛋白在冠状病毒跨宿主感染中的作用[J].微生物与感染,2013,8(1):43-51.

8 Graham RL,Baric RS.Recombination,reservoirs,and the modular spike:Mechanisms of coronavirus cross-species transmission[J].J Virol,2010,84(7):3134-3146.

9何丽红,刘文军,李晶.新型冠状病毒感染与复制的进展[J].生物工程学报,2020,36(10):1961-1969.

10 Satarker S,Nampoothiri M.Structural proteins in severe acute respiratory syndrome coronavirus-2[J].Arch Med Res,2020,51(6):482-491.

11 de Haan CA,Vennema H,Rottier PJ.Assembly of the coronavirus envelope:Homotypic interactions between the M proteins[J].J Virol,2000,74(11):4967-4978.

12 Neuman BW,Kiss G,Kunding AH,et al.A structural analysis of M protein in coronavirus assembly and morphology[J].J Struct Biol,2011,174(1):11-22.

13 Verdiá-Báguena C,Nieto-Torres JL,Alcaraz A,et al.Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids[J].Virology,2012,432(2):485-494.

14 Ortego J,Ceriani JE,Pati?o C,et al.Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway[J].Virology,2007,368(2):296-308.

15罗晓君,章文贤.冠状病毒的结构及生物学特性概述[J].生物学教学,2020,45(7):4-6.

16 Pyrc K,Dijkman R,Deng L,et al.Mosaic structure of human coronavirus NL63,one thousand years of evolution[J].J Mol Biol,2006,364(5):964-973.

17 Zhao Z,Li H,Wu X,et al.Moderate mutation rate in the SARS coronavirus genome and its implications[J].BMC Evol Biol,2004,4:21.

18穆雪纯,李丽,王凌航.新型冠状病毒流行变异株的分型及研究进展[J].国际病毒学杂志,2021,28(4):336-340.

19 Woo PC,Lau SK,Yip CC,et al.Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1[J].J Virol,2006,80(14):7136-7145.

20 Wong ACP,Lau SKP,Woo PCY.Interspecies jumping of bat coronaviruses[J].Viruses,2021,13(11):2188.

21 Boehm E,Kronig I,Neher RA,et al.Novel SARS-Co V-2variants:The pandemics within the pandemic[J].Clin Microbiol Infect,2021,27(8):1109-1117.

22王蓉,王彩红,姚晓文,等.新冠病毒变异株“缪”毒株的最新研究进展[J].海南医学院学报,2021,27(24):1841-1845.

23 Callaway E.Delta coronavirus variant:Scientists brace for impact[J].Nature,2021,595(7865):17-18.

24 Yang W,Shaman J.COVID-19 pandemic dynamics in India,the SARS-Co V-2 Delta variant,and implications for vaccination[J].med Rxiv[Preprint].2021,2021.06.21.21259268.

25 World Health Organization.Tracking SARS-Co V-2 variants,[EB/OL].(2021-12-06)[2021-12-10]https://www.who.int/en/activities/tracking-SARS-Co V-2-variants.

26郭爽.中国助力全球弥合“免疫鸿沟”[N].新华每日电讯,2021-12-08(007).

27 Gu H,Krishnan P,Ng DYM,et al.Probable transmission of SARS-Co V-2 omicron variant in quarantine hotel,Hong Kong,China,November 2021[J].Emerg Infect Dis,2022,28(2):460-462.

28奥密克戎已蔓延至57个国家和地区专家:未来或需接种第四剂疫苗[EB/OL].(2021-12-10)[2021-12-10].https://baijiahao.baidu.com/s?id=1718709939063246766&wfr=spider&for=pc.

29新华社记者.奥密克戎毒株已在至少38个国家和地区出现[N].新华每日电讯,2021-12-07(009).

30陈立希.韩总理要求全力防控应对奥密克戎[N].新华每日电讯,2021-12-08(007).

31郑可,赵凤英,青木,赵觉珵,任重,柳玉鹏.美欧深忧奥密克戎冲击[N].环球时报,2022-01-13(001).

32陶凤,赵天舒.奥密克戎蔓延加速美国心慌[N].北京商报,2021-12-06(008).

33南非两趟抵达荷兰班机61人新冠阳性,正检测是否为变异毒株Omicron[EB/OL].(2021-11-27)[2021-12-10].https://baijiahao.baidu.com/s?id=1717582173935059261&wfr=spider&for=pc.

34 Zhang L,Mann M,Syed ZA,et al.Furin cleavage of the SARS-Co V-2 spike is modulated by O-glycosylation[J].Proc Natl Acad Sci USA,2021,118 (47):e2109905118.

35 Wang R,Chen J,Hozumi Y,et al.Emerging vaccine-breakthrough SARS-Co V-2 variants[J].ACSInfect Dis,2022,8(3):546-556.

36 Chen J,Wang R,Wei GW.Review of the mechanisms of SARS-Co V-2 evolution and transmission[J].Ar Xiv[Preprint],2021,ar Xiv:2109.08148v1.

37 Chen J,Wang R,Gilby NB,et al.Omicron variant(B.1.1.529):Infectivity,vaccine breakthrough,and antibody resistance[J].J Chem Inf Model,2022,62(2):412-422.

38 Callaway E.The race for coronavirus vaccines:A graphical guide[J].Nature,2020,580(7805):576-577.

39 Dai L,Gao GF.Viral targets for vaccines against COV-ID-19[J].Nat Rev Immunol,2021,21(2):73-82.

40 Chen J,Gao K,Wang R,et al.Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies[J].Chem Sci,2021,12(20):6929-6948.

41 Chen J,Gao K,Wang R,et al.Revealing the threat of emerging SARS-Co V-2 mutations to antibody therapies[J].J Mol Biol,2021,433(18):167155.

42来势“汹汹”,症状“平平”?每经专访南非首个奥密克戎临床分析报告发布者[EB/OL].(2021-12-09)[2021-12-10].https://baijiahao.baidu.com/s?id=1718670686203173864&wfr=spider&for=pc.

43 100%预防新冠肺炎:再生元新冠中和抗体预防新冠病毒感染疗效显著[EB/OL].(2021-12-09)[2021-12-10].https://zhuanlan.zhihu.com/p/347389218.

基本信息:

DOI:10.13210/j.cnki.jhmu.20220128.001

中图分类号:R373

引用信息:

[1]高春,冯富娟,江晶晶,等.新冠病毒变异株“奥密克戎”的最新研究进展[J].海南医学院学报,2022,28(07):481-485.DOI:10.13210/j.cnki.jhmu.20220128.001.

基金信息:

第九四〇医院新冠肺炎应急医学科研项目(20yjky020); 火神山医院科研基金面上项目(HSS-217)~~

发布时间:

2022-01-28

出版时间:

2022-01-28

网络发布时间:

2022-01-28

引用

GB/T 7714-2015 格式引文
MLA格式引文
APA格式引文