| 1,807 | 26 | 16 |
| 下载次数 | 被引频次 | 阅读次数 |
<正>虾青素(astaxanthin)是从海洋动物(包括虾、蟹等甲壳类以及鲑鳟鱼类)中发现的一种红色类胡萝卜素。纯虾青素单质为暗红棕色粉末,但在体内虾青素可与蛋白质结合而呈青、蓝色。虾青素是一种氧化型类胡萝卜素,是类胡萝卜素生物合成途径中的终产物,化学名为3,3′-二羟基-4,4′-二酮基-β,β-
Abstract：1 Tanaka Y,Matsuguchi H,Katayama T,et al.The bio-synthesis of astaxanthin-XVI.The carotenoids inCrustacea[J].Comp Biochem Physiol B,1976,54:391-393.
2 Shahidi F,Metusalach A,Brown JA.Carotenoid pig-ments in seafoods and aquaculture[J].Crit Rev FoodSci Nutr,1998,38:1-67.
3 Chayen NE,Cianci M,Grossmann JG,et al.Unravel-ling the structural chemistry of the colouration mecha-nism in lobster shell[J].Acta Crystallogr D Biol Crys-tallogr,2003,59:2072-2082.
4张晓丽,刘建国.虾青素的抗氧化性及其在营养和医药应用方面的研究[J].食品科学,2006,(1):258-262.
5 Miki W.Biological functions and activities of animal ca-rotenoids[J].Pure Appl Chem,1991,63(1):141-146.
6 Suganuma K,Nakajima H.Astaxanthin attenuates theUVA-induced up-regulation of matrix-metalloprotein-ase-1and skin fibroblast elastase in human dermal fibro-blasts[J].J Dermatol Sci,2010,58(2):136-142.
7 Chew BP,Park JS.Carotenoid action on the immuneresponse[J].J Nutr,2004,134(1):257S-261S.
8 Ripathi DN,Jena GB.Astaxanthin intervention amelio-rates cyclophosphamide-induced oxidative stress,DNAdamage and early hepatocarcinogenesis in rat:Role ofNrf2,p53,p38and phase-Ⅱenzymes[J].Mutat Res,2010,696(1):69-80.
9 Pashkow FJ,Watumull DG.Astaxanthin:a novel po-tential treatment for oxidative stress and inflammationin cardiovascular disease[J].Am J Cardiol,2008,101(10A):58D-68D.
10 Otton R,Marin DP.Astaxanthin ameliorates the redoximbalance in lymphocytes of experimental diabetic rats[J].Chem Biol Interact,2010,186(3):306-315.
11 Stepnowski P,Olafsson G.Recovery of astaxanthinfrom seafood wastewater utilizing fish scales waste[J].Chemosphere,2004,54(3):413-417.
12 Dominguez-Bocanegra AR,Ponce-Noyola T.Astaxan-thin production by Phaffia rhodozyma and Haematococ-cus pluvialis:a comparative study[J].Appl MicrobiolBiotechnol,2007,75(4):783-791.
13 Misawa N.Pathway engineering of plants toward astax-anthin production[J].Plant Biotechnol,2009,26:93-99.
14 Choi S,Koo S.Efficient syntheses of the keto-carote-noids canthaxanthin,astaxanthin,and astacene[J].JOrg Chem,2005,70(8):3328-3331.
15 Johnson EA,An GH.Astaxanthin from microbialsources[J].Crit Rev Biotechnol,1991,11:297-326.
16 Visser H,van Ooyen AJJ,Verdoes JC.Metabolic engi-neering of the astaxanthin-biosynthetic pathway of Xan-thophyllomyces dendrorhous[J].FEMS Yeast Res,2003,(4):221-231.
17 Lorenz RT,Cysewski GR.Commercial potential forHaematococcus microalgae as a natural source of astax-anthin[J].Trends Biotechnol,2000,18:160-167.
18 Orosa M,Torres E,Fidalgo P,et al.Production andanalysis of secondary carotenoids in green algae[J].JAppl Phycol,2000,12:553-556.
19Renstrm B,Berger H,Liaaen-Jensen S.Esteried,op-tically pure(3S,3′S)-astaxanthin from flowers of Adon-is annua[J].Biochem Syst Ecol,1981,9:249-250.
20 Rodney M.Astaxanthin from flowers of the genus A-donis[P].United States Patent,5453565,1995-09-26.
21 Maoka T,Etoh T.Carotenoids and their fatty acid es-ters in the petals of Adonis aestivalis[J].J Oleo Sci,2011,60(2):47-52.
22 Mann V,Harker M.Metabolic engineering of astaxan-thin production in tobacco flowers[J].Nat Biotechnol,2000,18(8):888-892.
23 Gerjets T,Sandmann M.Metabolic engineering of keto-carotenoid biosynthesis in leaves and flowers of tobaccospecies[J].Biotechnol J,2007,2(10):1263-1269.
24 Ralley L,Enfissi EM.Metabolic engineering of keto-carotenoid formation in higher plants[J].Plant J,2004,39(4):477-486.
25 Hasunuma T,Miyazawa S.Biosynthesis of astaxanthinin tobacco leaves by transplastomic engineering[J].Plant J,2008,55(5):857-868.
26 Gerjets T,Sandmann G.Ketocarotenoid formation intransgenic potato[J].J Exp Bot,2006,57(14):3639-3645.
27 Morris WL,Ducreux LJ.Engineering ketocarotenoidbiosynthesis in potato tubers[J].Metab Eng,2006,8(3):253-263.
28 Stalberg K,Lindgren O.Synthesis of ketocarotenoidsin the seed of Arabidopsis thaliana[J].Plant J,2003,36(6):771-779.
29 Suzuki S,Nishihara M.Flower color alteration in Lotusjaponicus by modification of the carotenoid biosyntheticpathway[J].Plant Cell Rep,2007,26(7):951-959.
30 Zhu C,Naqvi S.Combinatorial genetic transformationgenerates a library of metabolic phenotypes for the ca-rotenoid pathway in maize[J].Proc Natl Acad SciUSA,2008,105(47):18232-18237.
31 Jayaraj J,Devlin R.Metabolic engineering of novel ke-tocarotenoid production in carrot plants[J].TransgenicRes,2008,17(4):489-501.
32 Fraser PD,Shimada H.Enzymic confirmation of reac-tions involved in routes to astaxanthin formation,eluci-dated using a direct substrate in vitro assay[J].Eur JBiochem,1998,252(2):229-236.
33 Zhu C,Naqvi S.Metabolic engineering of ketocarote-noid biosynthesis in higher plants[J].Arch BiochemBiophys,2009,483(2):182-190.
34 Cunningham FX Jr,Gantt E.A study in scarlet:en-zymes of ketocarotenoid biosynthesis in the flowers ofAdonis aestivalis[J].Plant J,2005,41(3):478-492.
35 Cunningham FX Jr.New biochemical route to Astaxan-thin[P].United States Patent,20100008871,2010-01-14.
基本信息:
DOI：10.13210/j.cnki.jhmu.2013.01.003
中图分类号:TQ914.2
引用信息:
[1]高新征,黄东爱,邬强,等.虾青素生产及其生物合成途径的研究进展[J].海南医学院学报,2013,19(01):141-144.DOI:10.13210/j.cnki.jhmu.2013.01.003.
基金信息:
国家自然科学基金资助项目(31160030)
2012-10-26
2012-10-26
2012-10-26