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目的：探讨体检人群中代谢综合征(metabolic syndrome,MS)及其不同组分高尿酸血症(hyperuricemia, HUA)流行特征。方法：纳入2021年6月～2023年3月在某医院健康管理中心的体检者作为研究对象。分析MS及其不同组分的HUA患病率，进一步将研究对象按性别分层，评估不同MS组分数量人群的血清尿酸水平(serum uric acid, SUA)和HUA患病率及两性中具有最高HUA患病率的MS组分组合方式；logistic回归分析不同MS组分数量人群HUA的患病风险。结果：共有66 520人纳入本次研究，MS组SUA水平(t=-82.947,P<0.001)和HUA患病率(χ2=3 421.632,P<0.001)显著高于非MS组。腹型肥胖、高血压、高密度脂蛋白胆固醇(HDL-C)降低和甘油三酯(TG)增高者的SUA水平和HUA患病率显著高于正常者(P<0.001)，而糖尿病患者SUA水平和HUA患病率存在性别差异，男性糖尿病患者SUA水平和HUA患病率显著低于血糖正常者，女性中这一结果相反。随MS组分数量增加，女性SUA水平和HUA患病率逐渐上升，而男性中，仅在MS1～MS4中观察到这样的趋势。男性HUA患病率最高的MS组分组合为腹型肥胖+高血压+HDL-C降低+TG增高(54.35%)，女性为腹型肥胖+高血压+糖尿病+HDL-C降低+TG增高(41.46%)。Logistic回归分析显示：校正性别、年龄和民族后，女性HUA的患病风险随着MS组分数量的增加而增加，而在男性中，MS1～MS4的HUA患病风险不断上升。进一步校正体重指数、总胆固醇增高、低密度脂蛋白增高、冠心病后，结果仍然一致。结论：体检人群中MS及其各组分是HUA的危险因素，MS组分的不同组合与HUA的相关性不同，HUA的患病风险与MS异常组分数量具有相关性。
Abstract：Objective: To explore the epidemiological characteristics of hyperuricemia(HUA) in the metabolic syndrome(MS) and its different components in the physical examination population. Methods: Subjects who underwent medical check-ups at a hospital health management center from June 2021 to March 2023 were included in the study. The prevalence of HUA in MS and its different components was analyzed, and the study population was further stratified by sex to assess serum uric acid(SUA) levels and HUA prevalence in different numbers of MS components and the combination of MS components with the highest HUA prevalence in both sexes. Logistic regression was used to analyze the risk of HUA in people with different numbers of MS components. Results: A total of 66 520 individuals were enrolled in the study. SUA levels(t=-82.947, P<0.001) and HUA prevalence(χ2=3 421.632, P<0.001) were significantly higher in the MS group than in the non-MS group. SUA levels and prevalence of HUA were significantly higher in abdominal obesity, hypertension, decreased HDL-C and evaluated TG than in normal subjects(P<0.001), while there were gender differences in SUA levels and HUA prevalence in diabetic patients, with significantly lower SUA levels and HUA prevalence in men with diabetes than in those with normal blood glucose, an opposite result in women. SUA levels and HUA prevalence gradually increased with the increasing number of MS components in women, whereas in men, such a trend was only observed in MS1～MS4. The combination of MS components with the highest prevalence of HUA was abdominal obesity + hypertension + decreased HDL-C + evaluated TG(54.35%) in men and abdominal obesity + hypertension + diabetes + decreased HDL-C + evaluated TG(41.46%) in women. Logistic regression analysis showed that after adjusting for gender, age and ethnicity, the risk of HUA increased with the number of MS components in women, while in men, the risk of HUA increased continuously from MS1 to MS4. Further adjustment for BMI, elevated TC, elevated LDL-C, and coronary artery disease, the results remained consistent. Conclusion: MS and its components are risk factors for HUA in the physical examination population, with different combinations of MS components having different correlations with HUA, and the risk of developing HUA correlates with the number of abnormal MS components.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20230825.002
中图分类号:R589.7;R589
引用信息:
[1]吴选霞,补娟,张艳敏,等.体检人群代谢综合征及其不同组分高尿酸血症流行特征研究[J].海南医学院学报,2023,29(20):1546-1554.DOI:10.13210/j.cnki.jhmu.20230825.002.
基金信息:
天山英才计划第二期第二层次项目（201720277）~~
2023-08-25
2023-08-25
2023-08-25