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目的:研究还原型谷胱甘肽治疗对早期糖尿病肾病患者血液指标的调节作用。方法:将我院收治的150例早期糖尿病肾病患者随机分为接受还原型谷胱甘肽联合常规药物治疗的抗氧化组(n=75)和接受常规药物治疗的对照组(n=75);治疗后4周,检测两组患者血清中氧化应激指标和肾功能指标。结果:抗氧化组患者血清中过氧化产物MDA、AOPP、8-OHdG含量低于对照组,抗氧化物质GSH-Px、NO和NOS的含量高于对照组(均P<0.05);抗氧化组患者血清中肾功能指标肌酐、尿素氮、CysC、RBP、NEFA、VEGF、Ang-2、FGF-2含量低于对照组(P<0.05)。结论:还原型谷胱甘肽治疗能够缓解氧化应激反应、改善肾脏功能,对于糖尿病肾病的治疗具有积极价值。
Abstract：Objective:To study the modulation effects of reduced glutathione treatment on blood indexes of patients with early diabetic nephropathy.Methods:150patients with early diabetic nephropathy treated in our hospital were randomly divided to antioxidant group(n=75)who received reduced glutathione combined with routine drug therapy.The control group(n=75)received routine drug therapy.Four weeks after treatment,serum oxidative stress indicators and renal function indicators of both groups were detected.Results:Peroxidation products MDA,AOPP and 8-OHdG contents in serum of antioxidant group were lower than those of control group,but antioxidants GSH-Px,NO and NOS contents were higher than those of control group.Renal function indexes creatinine,urea nitrogen,CysC,RBP,NEFA,VEGF,Ang-2and FGF-2contents in serum of antioxidant group were lower than those of control group.Conclusion:Reduced glutathione treatment can relieve oxidative stress response and improve renal function;it has positive value for the treatment of diabetic nephropathy.
1 Kundu S,Pushpakumar S,Sen U.MMP-9-and NMDA receptor-mediated mechanism of diabetic renovascular remodeling and kidney dysfunction:hydrogen sulfide is a key modulator[J].Nitric Oxide,2015,30(46):172-185.
2 Tang ZH,Zeng F,Zhang XZ.Human genetics of diabetic nephropathy[J].Ren Fail,2015,37(3):363-371.
3 Rosas-Díaz M,Camarillo-Cadena M,Hernández-Arana A,et al.Antioxidant capacity and structural changes of human serum albumin from patients in advanced stages of diabetic nephropathy and the effect of the dialysis[J].Mol Cell Biochem,2015,404(1-2):193-201.
4 Guo Y,Liu Y,Wang Y.Beneficial effect of lycopene on anti-diabetic nephropathy through diminishing inflammatory response and oxidative stress[J].Food Funct,2015,6(4):1150-1156.
5 Sauriasari R,Andrajati R,Azizahwati,et al.Marker of lipid peroxidation related to diabetic nephropathy in Indonesian type
2 diabetes mellitus patients[J].Diabetes Res ClinPract,2015,108(1):193-200.
6 Tesauro M,NisticòS,Noce A,et al.The possible role of glutathione-S-transferase activity in diabetic nephropathy[J].Int J Immunopathol Pharmacol,2015,28(1):129-133.
7 Sedighi O,Makhlough A,Shokrzadeh M,et al.Association between plasma selenium and glutathione peroxidase levels and severity of diabetic nephropathy in patients with type two diabetes mellitus[J].Nephrourol Mon,2014,6(5):e21355.
8 HakkiKalkan I,Suher M.The relationship between the level of glutathione,impairment of glucose metabolism and complications of diabetes mellitus[J].Pak J Med Sci,2013,29(4):938-942.
9 赵林双,向光大,杨李,等.8-羟基脱氧鸟苷酸和血管内皮生长因子与糖尿病肾病的关系[J].中国糖尿病杂志,2012,20(9):667-670.
10 Deng J,Wu G,Yang C,et al.Rosuvastatin attenuates contrast-induced nephropathy through modulation of nitric oxide,inflammatory responses,oxidative stress and apoptosis in diabetic male rats[J].J Transl Med,2015,13(1):53.
11 Tessari P.Nitric oxide in the normal kidney and in patients with diabetic nephropathy[J].J Nephrol,2015,28(3):257-68.
12 梁丽娟,洪宝建,方亚奇,等.血清CysC、RBP、NEFA联合检测在2型糖尿病肾病早期诊断中的临床价值[J].中国卫生检验杂志,2015,25(4):524-526.
13 Nosadini R,Tonolo G.Role of oxidized low density lipoproteins and free fatty acids in the pathogenesis of glomerulopathy and tubulointerstitial lesions in type 2diabetes[J].NutrMetabCardiovasc Dis,2011,21(2):79-85.
14 Dei Cas A,Gnudi L.VEGF and angiopoietins in diabetic glomerulopathy:how far for a new treatment?[J].Metabolism,2012,61(12):1666-1673.
基本信息:
DOI：10.13210/j.cnki.jhmu.20150720.015
中图分类号:R587.2
引用信息:
[1]靳新东,牛喜平.还原型谷胱甘肽对早期糖尿病肾病患者血液指标的作用[J].海南医学院学报,2015,21(12):1633-1635+1639.DOI:10.13210/j.cnki.jhmu.20150720.015.
基金信息:
河南省自然科学研究计划项目(201310471055)~~
2015-07-20
2015-07-20
2015-07-20