海南医科大学学报

目的:观察丙泊酚联合芬太尼在治疗性ERCP检查中应用的效果及安全性。方法:286例ASAⅠ～Ⅲ级择期行治疗性ERCP的患者随机分成丙泊酚麻醉组(P组)和丙泊酚联合芬太尼麻醉组(PF组),每组143例。记录每组患者术前、术中、术后的MAP、HR、SpO2、丙泊酚用量及手术持续时间、术毕患者的苏醒时间、麻醉期间的不良反应如舌后坠、肢体扭动、呼吸抑制等。结果:PF组术中MAP、HR变化与术前、P组比较差异有统计学意义(P<0.05),PF组苏醒、离院时间及丙泊酚用量小于P组(P<0.05)。结论:丙泊酚联合芬太尼在治疗性ERCP中应用是安全有效的,值得推广。

Objective:To investigate the quality and safety of propofol combined with fentanly in therapeutic endosccopic retrograde cholangiopangiopancreatography(ERCP).Methods:Two hundred sixty-four patients with ASAⅠ～Ⅲ underwent therapeutic ERCP and were randomly assigned into two groups(n=132 each):P group and PF group.Patients in P group were treated with propofol,while patients in PF group with propofol combined with fentanly.The parameter,such as MAP,HR,SpO2,dose of propofol,duration of surgery,recovery time,and adverse effect including glossoptosis,twisted body and respiratory depression were observed and recorded.Results:The changes of MAP,HR were significant in group P after surgery,and the difference was also significant between two groups(P<0.05).The recovery time and discharged time were significanly shorter in group PF and the dose of propofol in group PF was less than that in group P(P<0.05).Conclusions:Propofol combined with fentanly provides safe and effective sedation in therapeutic ERCP,which can be widely used.