海南医科大学学报

目的:研究等离子射频消融术治疗腺样体肥大的术中创伤程度及术后免疫功能、通气功能。方法:选择在本院接受手术治疗的腺样体肥大患儿118例,按照单盲随机对照法分为接受常规鼻内镜下切割吸引刀的对照组59例,接受等离子射频消融术的观察组59例。手术前后,测定外周血创伤相关指标、体液免疫及补体指标、鼻通气功能指标水平。结果:术前,两组创伤相关指标、体液免疫及补体指标、鼻通气功能指标的差异无统计学意义(P>0.05)。手术结束即刻,观察组外周血SP、PGE2、CRP含量低于对照组(P<0.05);术后24h,观察组外周血IgG、IgM、IgA、C3、C4含量低于对照组(P<0.05);术后1周,观察组TIR、TER水平低于对照组,NPV、MCSA水平高于对照组(P<0.05)。结论:等离子射频消融术用于腺样体肥大治疗,术中创伤较小,在优化机体免疫功能及通气功能方面更具优势。

Objective:To study the intraoperative wound degree as well as postoperative immune function and ventilation function of plasma radiofrequency ablation for the treatment of adenoid hypertrophy.Methods:A total of 118 children with adenoid hypertrophy who underwent surgical treatment in our hospital between May 2013 and April 2016 were selected and divided into the control group(n=59)who accepted conventional endoscopic cutting aspirator and the observation group(n=59)who accepted the plasma radiofrequency ablation according to the single-blind randomized controlled method.Before and after operation,the levels of peripheral blood trauma-related indexes,humoral immunity and complement indexes as well as nasal ventilation function indexes were determined.Results:Before operation,the differences in trauma-related indexes,humoral immunity and complement indexes as well as nasal ventilation function indexes were not statistically significant between two groups of children(P>0.05).Immediately after operation,the peripheral blood SP,PGE2 and CRP contents of observation group were lower than those of control group(P<0.05);24hafter operation,peripheral blood IgG,IgM,IgA,C3 and C4contents of observation group were lower than those of control group(P<0.05);1week after operation,TIR and TER levels of observation group were lower than those of control group while NPV and MCSA levels were higher than those of control group(P<0.05).Conclusions:Plasma radiofrequency ablation for treatment of adenoid hypertrophy causes smaller intraoperative wound and has more advantages in optimizing the body's immune function and ventilation function.