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目的:探讨添加双歧杆菌的肠内营养干预对重症脑梗死患者营养状态及肠道菌群紊乱的影响。方法:收集本院收治的重症脑梗死患者88例,随机将入组患者分为对照组、观察组,对照组接受常规肠内营养干预,观察组接受添加双歧杆菌的肠内营养干预。对比两组营养干预前后营养状态、肠黏膜功能及肠道菌群分布情况的差异。结果:干预前,两组营养状态、肠黏膜功能及肠道菌群分布情况的差异无统计学意义(P>0.05)。干预后,观察组外周血中营养状态指标Hb、TP、ALB、PA、TF的含量高于对照组;血清中肠黏膜屏障功能指标DAO、D-乳酸的含量低于对照组;粪便中双歧杆菌、乳杆菌的数量大于对照组,肠杆菌、肠球菌的数量小于对照组(P<0.05)。结论:添加双歧杆菌的肠内营养干预可增强重症脑梗死患者的营养状态、优化肠黏膜功能,减轻肠道菌群分布紊乱。
Abstract：Objective:To study the effects of bifidobacterium-containing enteral nutrition intervention on the nutritional status and intestinal flora disturbance in patients with the severe cerebral infarction.Methods:A total of 88 patients with severe cerebral infarction who were treated in Deyang Second People's Hospital between March 2014 and October 2016 were collected and divided into control group and observation group according to the random number table,control group received routine enteral nutrition intervention,and the observation group received bifidobacterium-containing enteral nutrition intervention.The nutritional status,intestinal mucosa function and intestinal flora distribution before and after nutritional intervention were compared between the two groups of patients.Results::Before intervention,differences in the nutritional status,intestinal mucosa function and intestinal flora distribution were not statistically significant between two groups of patients(P>0.05).After intervention,peripheral blood levels of nutritional status indexes Hb,TP,ALB,PA and TF in observation group were higher than those in control group;serum levels of intestinal mucosal barrier function indexes DAO and D-lactate were lower than those in control group;the number of bifidobacterium and lactobacillus in feces were larger than those in control group while the number of enterobacteria and enterococcus were smaller than those in control group(P<0.05).Conclusions:Bifidobacterium-containing enteral nutrition intervention can enhance the nutritional status,optimize the intestinal mucosa function and reduce the intestinal flora disturbance in patients with severe cerebral infarction.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20170627.015
中图分类号:R743.33
引用信息:
[1]张毅,王军,朱海龙,等.添加双歧杆菌的肠内营养干预对重症脑梗死患者营养状态及肠道菌群紊乱的影响[J].海南医学院学报,2017,23(12):1723-1725+1729.DOI:10.13210/j.cnki.jhmu.20170627.015.
基金信息:
德阳市科学技术和知识产权局基金(2014SZ037)~~
2017-06-27
2017-06-27
2017-06-27