海南医科大学学报

目的:探讨氧气驱动雾化吸入布地奈德对急性喉炎的临床疗效。方法:选取河北钢铁集团宣钢职工医院2014年4月~2015年4月收治的70例急性喉炎患者,所有患者随机分为两组,在常规治疗基础上,观察组以氧气驱动雾化吸入布地奈德,对照组以氧气驱动雾化吸入地塞米松治疗。观察治疗前和治疗30min后两组血氧饱和度(SpO₂)变化情况、治疗前和治疗3d后血清白细胞介素-4(IL-4)及白细胞介素-8(IL-8)炎症因子变化,观察两组用药后临床症状消失时间及住院时间及临床治疗效果。结果:治疗30min后SpO₂改善程度观察组明显优于对照组(P<0.05);治疗3d后观察组IL-4、IL-8水平下降程度明显优于对照组(P<0.05);观察组临床症状消失时间及住院时间少于对照组(P<0.05);观察组总有效率为94.3%,优于对照组的74.3%,差异有统计学意义(P<0.05)。结论:氧气驱动雾化吸入布地奈德治疗急性喉炎可迅速减轻局部炎症反应,改善临床症状,提高用药安全性,值得临床推广。

Objective:To explore the clinical efficacy of oxygen-driven atomizing inhalation of budesonide in the treatment of acute laryngitis.Methods:Based on the routine treatment,patients in the observation group were given oxygen-driven atomizing inhalation of budesonide,while the patients in the control group were given oxygen-driven atomizing inhalation of dexamethasone.The change of SpO₂ before treatment and 30 min after treatment,the changes of serum IL-4 and IL-8 before treatment and 3d after treatment,the clinical symptom disappearing time,hospitalization time,and clinical therapeutic effect after drug administration in the two groups were observed.Results:The improved degree of SpO₂ 30 min after treatment in the observation group was more significant than that in the control group(P<0.05).The decreased degree of IL-4 and IL-8 levels 3 dafter treatment in the observation group was more significant than that in the control group(P<0.05).The clinical symptom disappearing time and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05).The total effective rate in the observation group(94.3%)was significantly higher than that in the control group(74.3%)(P<0.05).Conclusions:Oxygen-driven atomizing inhalation of budesonide in the treatment of acute laryngitis can rapidly alleviate the local inflammatory reaction,improve the clinical symptoms,and enhance the safety of drug administration;therefore,it deserves to be widely recommended in the clinic.