海南医科大学学报

目的:探讨盐酸氨溴索联合康复训练对慢阻肺的临床疗效及其对患者肺功能的影响。方法:将本院收治的92例稳定期COPD患者随机分为对照组(n=46)与观察组(n=46)。对照组采用吸氧、祛痰、解痉、抗感染等常规治疗,观察组在此基础上采用盐酸氨溴索联合康复训练治疗。比较两组治疗前后血气指标、肺功能、炎性因子指标水平。结果:两组治疗后SaO₂及PaO₂水平较治疗前均上升,PaCO₂水平较治疗前均下降,差异均具有统计学意义(P<0.05)。两组治疗后血清IL-6及IL-8水平较治疗前下降,差异具有统计学意义(P<0.05)。观察组治疗后肺功能相关指标水平均高于治疗前及对照组治疗后,差异具有统计学意义(P<0.05)。结论:盐酸氨溴索联合康复训练对慢阻肺的临床疗效显著,可有效改善患者血气指标、降低血气炎性因子水平,对患者肺功能产生影响。

Objective: To explore the clinical effect of ambroxol hydrochloride combined with rehabilitation training on COPD and its effect on pulmonary function. Methods: Totally 92 patients with COPD from May 2017 to may 2019 were randomly divided into control group(n=46) and observation group(n=46). The control group was treated with oxygen inhalation, expectorant, antispasmodic, antiinfection etc. The observation group was treated with ambroxol hydrochloride combined with rehabilitation training on this basis. Blood gas, lung function and inflammatory factors were compared before and after treatment. Results: ① the levels of SaO₂ and PaO₂ in the two groups were significantly higher than those before treatment(P There was significant difference between the two groups(P<0.05-0.01). ③ the level of lung function related indexes in the observation group was significantly higher than that in the control group(P<0.05). Conclusion: Ambroxol hydrochloride combined with rehabilitation training has a significant clinical effect on COPD, which can effectively improve the blood gas index and reduce the level of blood gas inflammatory factors, thus affecting the lung function of COPD patients.