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目的:分析丹参川芎嗪辅助治疗对慢性肾功能衰竭患者肾功能、肾血流灌注及结缔组织生长因子(CTGF)、转化生长因子(TGF)-β1含量的影响。方法:选择2013年3月~2016年3月本院收治的80例慢性肾功能不全患者进行研究,随机分为观察组及对照组,对照组接受常规治疗,观察组接受常规+丹参川芎嗪辅助治疗。治疗后3个月后,测定两组肾功能指标、病情相关指标、肾血流灌注及CTGF、TGF-β1含量等差异。结果:治疗3个月后,观察组血清中尿素氮(BUN)、肌酐(Scr)、β2微球蛋白(β2-MG)、中叶素(IMD)、成纤维细胞生长因子23(FGF23)、胱抑素C(Cys C)、CTGF、TGF-β1含量以及尿液中24 h尿白蛋白排泄率(UAER)水平均显著低于对照组,肾小球滤过率(GFR)水平及血清中脂联素(APN)含量均显著高于对照组;观察组肾血流灌注参数肾皮质达峰时间(ATc)、髓质达峰时间(ATm)水平显著低于对照组,皮质峰值强度变化(ΔAc)、髓质峰值强度变化(ΔAm)、峰值强度(PI)水平显著高于对照组。结论:丹参川芎嗪辅助治疗可有效控制慢性肾功能衰竭患者整体病情,在提升肾功能、增加肾脏血流灌注方面具有积极作用。
Abstract：Objective: To analyze the effect of adjuvant salvia miltiorrhiza and ligustrazine therapy on renal function,renal blood perfusion as well as CTGF and TGF-β1 content in patients with chronic renal failure. Methods: A total of 80 patients with chronic renal insufficiency treated in our hospital between March 2013 and March 2016 were selected for study and randomly divided into observation group and control group,control group received conventional therapy and observation group received conventional + adjuvant salvia miltiorrhiza and ligustrazine therapy. After 3 months of treatment,differences in renal function indexes,illness-related indexes,renal blood perfusion,connective tissue growth factor( CTGF) and transforming growth factor( TGF)-β1 content,and so on of two groups of patients were determined. Results: After 3 months of treatment,serum BUN,Scr,β2-MG,IMD,FGF23,Cys C,CTGF and TGF-β1 content as well as UAER level in urine of observation group were significantly lower than those of control group while GFR level and serum APN content were significantly higher than those of control group; renal perfusion parameters ATc and ATm levels of observation group were significantly lower than those of control group while ΔAc,ΔAm and PI levels were significantly higher than those of control group. Conclusions: Adjuvant salvia miltiorrhiza and ligustrazine therapy can effectively control the overall condition of patients with chronic renal failure,and plays a positive role in improving renal function and increasing renal blood perfusion.
1 Gurbuz N,Kol A,Ipekci T,et al.Chronic administration of sildenafil improves erectile function in a rat model of chronic renal failure[J].Asian J Androl,2015,17(5):797-801.
2 杨金友,张巧玲,孙莉莉,等.慢性肾功能衰竭影响因素的病例对照研究[J].中国全科医学,2015,18(4):413-416.
3 马旭,朱清,邵凤民.丹参川芎嗪注射剂对老年慢性肾功能衰竭患者血清结缔组织生长因子及转化生长因子-β1的影响[J].中国老年学杂志,2015,35(16):4640-4643.
4 陈飞,邹天南,覃芳.康肾颗粒对非透析慢性肾功能衰竭患者肾功能及微炎症状态的影响[J].实用临床医药杂志,2015,19(5):103-105.
5 李仁战,樊树峰.碘佛醇对冠脉介入造影血清APN、hs-CRP、IMA及肾功能的影响[J].中国生化药物杂志,2016,1(36):95-98.
5 Soni HM,Patel PP,Patel S,et al.Effects of combination of aliskiren and pentoxyfylline on renal function in the rat remnant kidney model of chronic renal failure[J].Indian J Pharmacol,2015,47(1):80-85.
6 Gharishvandi F,Kazerouni F,Ghanei E,et al.Comparative assessment of neutrophil gelatinase-associated lipocalin(NGAL)and cystatin C as early biomarkers for early detection of renal failure in patients with hypertension[J].Iran Biomed J,2015,19(2):76-81.
7 李静,徐彤彤,余帆.联合检测血清IMD、FGF23及Cys C对高血压早期肾功能损伤的评估价值[J].广东医学,2015,36(7):1098-1100.
8 王瑾,徐文军.小剂量利尿剂联合大黄蛰虫丸对慢性肾功能衰竭患者血清睾酮胱抑素C、瘦素及2微球蛋白水平影响研究[J].中国生化药物杂志,2015,11(35):144-147.
9 Sit D,Basturk T,Yildirim S,et al.Evaluation of the serum cystatin C values in prediction of indications for hemodialysis in patients with chronic renal failure[J].Int Urol Nephrol,2014,46(1):57-62.
10 Wehbe E,Patarroyo M,Taliercio JJ,et al.Renal failure requiring dialysis complicating slow continuous ultrafiltration in acute heart failure:importance of systolic perfusion pressure[J].J Card Fail,2015,21(2):108-115.
11 Waeckel L,Bertin F,Clavreul N,et al.Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure[J].Pflugers Arch,2015,467(4):817-831.
12 Caobelli F,Bengel FM.Further evidence for the robustness of regadenoson stress myocardial perfusion SPECT:its predictive value for cardiac events in chronic renal failure[J].Eur Heart J Cardiovasc Imaging,2014,15(8):941-942.
13 刘勋华.尿毒清胶囊对慢性肾功能衰竭患者血清CTGF、TGF-β1的影响[J].中国现代医学杂志,2014,24(15):44-46.
14 Yiang GT,Chen JN,Lin PS,et al.Combined treatment with vitamin E and gefitinib has synergistic effects to inhibit TGF-β1-inducedrenal fibroblast proliferation[J].Mol Med Rep,2016,13(6):5372-5378.
15 Hu N,Duan J,Li H,et al.Hydroxysafflor yellow a ameliorates renal fibrosis by suppressing TGF-β1-induced epithelial-to-mesenchymal transition[J].PLo S One,2016,11(4):e0153409.
16 刘静.右美托咪定对颈动脉内膜剥脱术患者脑氧代谢神经功能以及炎症反应的调节作用[J].海南医学院学报,2016,22(11):1081-1083.
17 Li X,Diao Z,Ding J,et al.The downregulation of Sno N expression in human renal proximal tubule epithelial cells under high-glucose conditions is mediated by an increase in Smurf2 expression through TGF-β1 signaling[J].Int J Mol Med,2016,37(2):415-422.
基本信息:
DOI：10.13210/j.cnki.jhmu.20161027.007
中图分类号:R692.5
引用信息:
[1]管海玉.丹参川芎嗪辅助治疗对慢性肾功能衰竭患者肾功能、肾血流灌注及CTGF、TGF-β1含量的影响[J].海南医学院学报,2017,23(01):59-61+65.DOI:10.13210/j.cnki.jhmu.20161027.007.
基金信息:
广东省科技计划项目(2012B031600471)~~
2016-10-27
2016-10-27
2016-10-27