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目的:研究芪参益气滴丸辅助治疗对早期糖尿病肾病患者肾功能变化及病情转归的影响。方法:选择我院收治的早期糖尿病肾病患者,随机分为两组,观察组接受芪参益气滴丸联合常规治疗,对照组接受常规治疗,比较治疗前及治疗后3个月时的肾功能指标、细胞因子含量、氧自由基生成量。结果:两组治疗后的尿UREA水平及血清β2微球蛋白(β2-MG)、胱抑素C(CysC)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、基质细胞衍生因子-1(SDF-1)、白细胞介素-17(IL-17)、转化生长因子-β1(TGF-β1)、丙二醛(MDA)、8-异前列腺素F2α(8-iso-PGF2α)含量均明显降低,超氧化物歧化酶(SOD)、总抗氧化力(T-AOC)含量明显升高,且观察组治疗后的尿UREA水平及血清β2-MG、CysC、TNF-α、IL-6、SDF-1、IL-17、TGF-β1、MDA、8-iso-PGF2α均明显低于对照组,SOD、T-AOC含量明显高于对照组。结论:芪参益气滴丸辅助治疗早期糖尿病肾病能够改善肾功能并减轻炎症及氧化应激反应的程度。
Abstract：Objective:To study the effects of adjuvant Qishen Yiqi Drop Pill therapy on renal function changes and prognosis of patients with early diabetic nephropathy.Methods:The patients with early diabetic nephropathy treated in our hospital between February 2015 and April 2017 were chosen and divided into two groups by random number table,observation group received Qishen Yiqi Drop Pill combined with conventional therapy and control group accepted conventional therapy.The renal function indexes,cytokine contents and oxygen free radical generation were compared before treatment and 3 months after treatment.Results:Urine UREA levels as well as serum β2 microglobulin(β2-MG),cystatin C(CysC),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),stromal cell-derived factor-1(SDF-1),interleukin-17(IL-17),transforming growth factor-β1(TGF-β1),malondialdehyde(MDA)and 8-iso-prostaglandin F2α(8-iso-PGF2α)contents of both groups were significantly lower while superoxide dismutase(SOD)and total antioxidant capacity(T-AOC)contents were significantly higher after treatment,and urine UREA level as well as serum β2-MG,CysC,TNF-α,IL-6,SDF-1,IL-17,TGF-β1,MDA and 8-iso-PGF2α contents of observation group after treatment was significantly lower than those of control group while SOD and T-AOC contents were significantly higher than those of control group.Conclusion:Adjuvant Qishen Yiqi Drop Pill therapy can improve the renal function and reduce the inflammatory response and oxidative stress response in early diabetic nephropathy.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20181219.003
中图分类号:R259;R277.5
引用信息:
[1]李君,张小红.芪参益气滴丸辅助治疗对早期糖尿病肾病患者肾功能变化及病情转归的影响[J].海南医学院学报,2019,25(03):190-193.DOI:10.13210/j.cnki.jhmu.20181219.003.
基金信息:
长江大学黄冈临床医学院(WJ2016-Y-47)~~
2018-12-20
2018-12-20
2018-12-20