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目的:研究糖尿病肾病患者血清25羟维生素D含量对病情评估的价值。方法:选择健康体检者、2型糖尿病患者、糖尿病肾病患者分别作为对照组、糖尿病组、糖尿病肾病组,检测血清中25羟维生素D、RAS分子、趋化因子含量以及尿液中足细胞损伤分子的含量。结果:血清25羟维生素D含量及尿液Nephrin、Podocin、CD2相关蛋白(CD2AP)、α3β1整合素的含量均呈现糖尿病肾病组<糖尿病组<对照组的趋势,且大量蛋白尿患者的血清25羟维生素D含量及尿液Nephrin、Podocin、CD2AP、α3β1整合素的含量均显著低于微量蛋白尿组(P<0.05);血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、单核细胞趋化蛋白(MCP-1)、趋化因子(FKN)、血管细胞黏附分子-1(VCAM-1)、细胞间黏附分子(ICAM-1)、骨桥蛋白(OPN)、巨噬细胞移动抑制因子(MIF)含量及尿液Nesmin含量均呈现糖尿病肾病组>糖尿病组>对照组的趋势,大量蛋白尿患者的血清PRA、AngⅡ、ALD、MCP-1、FKN、VCAM-1、ICAM-1、OPN、MIF含量及尿液Nesmin含量均显著高于微量蛋白尿组(P<0.05)。结论:糖尿病肾病患者血清25羟维生素D含量显著降低,同时能够评估RAS系统活性、炎性反应程度、足细胞损伤程度。
Abstract：Objective:To assess the value of serum 25-hydroxy-vitamin D content detection for patients with diabetic nephropathy.Methods:Healthy subjects,patients with type 2diabetes mellitus and patients with diabetic nephropathy were selected for study and enrolled in control group,diabetes group and diabetic nephropathy group respectively,and contents of25-hydroxy-vitamin D,RAS molecules and chemokines in serum as well as contents of podocyte injury molecules in urine were detected.Results:Serum 25-hydroxy-vitamin D content as well as Nephrin,Podocin,CD2 AP andα3β1integrin contents in urine all showed the trend of diabetic nephropathy group < diabetes group < control group,and serum 25-hydroxy-vitamin D content as well as Nephrin,Podocin,CD2 AP andα3β1integrin contents in urine of patients with macroalbuminuria were significantly lower than those of patients with microalbuminuria;contents of PRA,AngⅡ,ALD,MCP-1,FKN,VCAM-1,ICAM-1,OPN and MIF in serum as well as contents of Nesmin in urine all showed the trend of diabetic nephropathy group> diabetes group > control group,and contents of PRA,AngⅡ,ALD,MCP-1,FKN,VCAM-1,ICAM-1,OPN and MIF in serum as well as contents of Nesmin in urine of patients with macroalbuminuria were significantly higher than those of patients with microalbuminuria.Conclusions:Serum 25-hydroxy-vitamin D content significantly decreases in patients with diabetic nephropathy,and it can also assess the activity of RAS system,the degree of inflammatory response and the degree of podocyte injury.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20160214.007
中图分类号:R587.2;R446.11
引用信息:
[1]罗君,陈莉农,郭奇,等.糖尿病肾病患者血清25羟维生素D含量检测对病情评估的价值[J].海南医学院学报,2016,22(10):984-987.DOI:10.13210/j.cnki.jhmu.20160214.007.
基金信息:
四川省科技计划项目(2013fz0080)~~
2016-05-28
2016-05-28