海南医科大学学报

目的:探索阿托伐他汀对患有高血压疾病患者血清炎性因子、血管内皮功能以及血脂水平的影响。方法:研究对象选自2012年10月~2014年6月期间我院门诊收治的128例高血压患者,按照其门诊就诊顺序随机分成两组,对照组64例进行常规降压药物治疗,观察组64例则在常规治疗的基础上加服阿托伐他汀,治疗8周后,观察比较患者血脂指标、血清炎性因子水平以及血管内皮功能的变化。结果:治疗后观察组白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP)水平分别为(121.72±24.60)ng/L、(14.12±2.62)ng/mL和(5.68±0.59)mg/L,均较治疗前明显降低,且各指标显著低于对照组(P<0.05)。而治疗后对照组IL-6、TNF-α及hs-CRP与治疗前比较无明显变化(P>0.05);治疗后观察组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)分别为(4.18±0.49)、(1.21±0.39)、(2.42±0.47)mmol/L,高密度脂蛋白胆固醇(HDL-C)为(1.57±0.21)mmol/L,均较治疗前明显改善,且组间差异有统计学意义(P<0.05)。而对照组上述各项指标均无明显变化(P>0.05);治疗后观察组内皮素(ET)、一氧化氮(NO)、肱动脉血流介导的血管扩张率(FMD)分别为(42.18±16.35)pg/mL、(18.09±2.41)μmol/L、(15.46±2.18)%,均较治疗前明显改善,且与对照组间差异有统计学意义(P<0.05);两组患者含服硝酸甘油后血管内径变化率(GTN)治疗前后均无显著性变化(P>0.05)。结论:阿托伐他汀对高血压疾病患者具有较好的疗效,应用价值较高。

Objective:To explore the effect of atorvastatin on serum inflammatory factors,vascular endothelial function and blood lipid level of patients with hypertension.Methods:A total of 128 cases of hypertension in our hospital were randomly divided into two groups according to the order of outpatients.64 cases in the control group of conventional antihypertensive drug therapy,on the basis of conventional therapy,the observation group of 64 cases were given atorvastatin.Eight weeks after treatment,changes of blood lipid indexes and serum level of inflammatory factors and endothelial function were observed and compared.Results:After the treatment,IL-6,TNF-alpha and hs-CRP levels of the observation group were(121.72±24.60)ng/L,(14.12±2.62)ng/mL and(5.68± 0.59)mg/L,were significantly lower than those before therapy,and each index was significantly lower than the control group(P<0.05).While compared with before treatment,IL-6,TNF-alpha and hs-CRP levels of the control group after treatment had no significant change(P>0.05).After the treatment,were observed in group TC,TG,LDL-C levels of the observation group were(4.18 ±0.49)mmol/L,(1.21 ±0.39)mmol/L,(2.42±0.47)mmol/L,HDL-C(1.57±0.21)mmol/L,were significantly improved compared with before treatment,the difference was statistically significant between the groups(P<0.05).While above indexes of the control group showed no significant change(P>0.05).After the treatment,ET,NO,FMD levels of the observation group were(42.18±16.35)pg/mL,(18.09±2.41)mol/L,(15.46±2.18)% were significantly improved,and there was a statistically significant difference between the two groups(P<0.05).GTN level of the two groups before and after treatment had no significant change(P> 0.05).Conclusion:Atorvastatin has good curative effect on hypertension patients,has higher application value.