海南医科大学学报

目的:探讨丹参多酚酸盐对不稳定型心绞痛(UAP)患者相关细胞因子的影响。方法:选取50例UAP患者为研究对象,随机分为治疗组与对照组,两组均常规卧床休息、吸氧、心电监护、硝酸甘油静脉持续泵入、β-受体阻滞剂、口服阿斯匹林、抗血小板药物、他汀类等治疗,治疗组在此基础上加用丹参多酚酸盐200mg+5%葡萄糖液250mL(糖尿病患者用0.9%氯化钠液或葡萄糖加中和量胰岛素)静脉点滴,1次/d,两组疗程均为2周;检测治疗前后血浆血清妊娠相关蛋白A(PAPP-A)、可溶性白细胞分化抗原配体(sCD40L)水平及血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平。结果:疗程结束后治疗组PAPP-A、sCD40L水平降低程度优于对照组,差异有统计学意义(P<0.05);治疗组IL-1、IL-6、TNF-α水平降低程度优于对照组,差异有统计学意义(P<0.05)。结论:在常规治疗基础上加用丹参多酚酸盐对UAP进行治疗,可明显抑制血小板聚集,控制炎性反应,稳定动脉硬化斑块,降低心血管事件发生风险而发挥疗效,值得临床推广。

Objective:To investigate the effect of Salvia miltiorrhiza(SM)on cytokines in patients with unstable angina pectoris(UAP).Methods:A total of 50 cases UAP patients as the research objects,and randomly divided into treatment group and control group.Two groups were treated with conventional bed rest,oxygen inhalation,ECG,nitroglycerin intravenous infusion,beta blockers,aspirin,statins,antiplatelet drug therapy,and on the basis of above the treatment group was treated 200 mg salvianolate+250mL 5% glucose intravenous drip(neutralization amount of 0.9% sodium chloride was used in patients with diabetes or glucose insulin),1times/d.Two groups were treated for 2weeks;plasma pregnancy associated plasma protein A(PAPP-A),soluble cell differentiation antigen ligand(sCD40L)and the level of serum interleukin-1(IL-1),interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-alpha)level were detected before and after treatment.Results:After treatment,the levels of PAPP-A and sCD40 Lof treatment group decreased significantly than those of control group,which had statistical significance(P<0.05);IL-1,IL-6,TNF-a levels of treatment group were lower than those of control group,which had statistical significance(P<0.05).Conclusion:On the basis of conventional treatment,adding salvianolate in treatment ofUAP can inhibit platelet aggregation,control inflammatory reaction,stabilize atherosclerotic plaque,reduce risk of cardiovascular events in therapeutic effect,and it is worth clinical promotion.