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目的:对苯佐卡因的合成工艺进行探索。方法:以对硝基苯甲酸为起始原料,经酯化,还原两步合成苯佐卡因。结果:目标化合物经红外、熔点确证,总收率为55%。结论:该工艺操作简便,适用于学生实验的教学。
Abstract：Objective: To improve the preparation of benzocaine.Methods: Benzocaine was synthesized from р-nitrobenzoic acid via two steps through esterifying and reduction.Results: The structure of final compoud was confirmed by IR、melting point,and the overall yield was 55%.Conclusion: The method is simple and suitable for the teaching of medicinal chemistry experiment.
1尤启冬.药物化学实验与指导[M].北京:中国医药科技出版社,2000.90-122.
2卢忠.苯佐卡因的制备方法[J].数理医药杂志,2000,13(5):445-446.
3马俊林,刘栓柱.苯佐卡因的合成研究[J].士堰职业技术学院学报,2001,14(2):74-77.
4黄克明.苯佐卡因合成工艺改进[J].广东药学院学报,1998,14(4):293-294.
基本信息:
DOI：10.13210/j.cnki.jhmu.2007.02.028
中图分类号:TQ463.2
引用信息:
[1]欧守珍,陈年根,任兆平,等.苯佐卡因合成工艺的改进[J].海南医学院学报,2007,No.57(02):164-165.DOI:10.13210/j.cnki.jhmu.2007.02.028.
2007-04-28
2007-04-28