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目的:以浸膏收率、总皂苷含量、斯皮诺素含量为指标,优选酸枣仁药材水提取工艺。方法:采用正交试验,考察煎煮时间、提取次数和加水倍量3个因素,对酸枣仁药材水提取工艺条件进行优化。结果:酸枣仁药材最佳水提取工艺条件为加10倍量水浸泡过夜,加热煎煮3次,每次1h。结论:该提取工艺稳定可行,重现性好,适于酸枣仁药材水提取。
Abstract：Objective: To optimize the water extraction technology of Ziziphi spinosae Semen with the targets of the yield of dry extract,the content of total saponins and the content of spinosin as indices.Methods: The decoction time,extraction times and the amount of water were investigated as factors in orthogonal design tests,and each factor with three levels.Results: The optimum extraction technology was that the crude drug powder was macerated with 12 times equivalent volume of water for overnight and refluxed 3 times,each time 1 h.Conclusions:The optimum technology is stable,reproducible and suitable for the extraction of Ziziphi spinosae Semen.
1中华人民共和国国家药典委员会.中华人民共和国药典[S].1部.北京:化学工业出版社,2010:343.
2马进杰,刘萍,马百平.酸枣仁化学成分及其镇静催眠作用研究进展[J].国际药学研究杂志,2011,38(3):206-211.
3高声传,郭涛.比色法测定酸枣仁提取物中总皂苷的含量[J].中国现代中药,2005,8(1):15-16.
基本信息:
DOI：10.13210/j.cnki.jhmu.2011.11.002
中图分类号:R284
引用信息:
[1]王勇,魏娜,徐爽,等.多指标正交试验法优选酸枣仁药材水提取工艺[J].海南医学院学报,2011,17(11):1452-1456.DOI:10.13210/j.cnki.jhmu.2011.11.002.
基金信息:
海南医学院科研基金资助学报项目(0020110401)~~
2011-09-09
2011-09-09
2011-09-09