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心力衰竭是各种心脏疾病导致心功能不全一种持续发展综合征，不仅患病率持续升高，且死亡率和再次住院率居高不下。心力衰竭也是心血管疾病的终末期以及患者死亡主要的原因，严重影响着世界各地人们的身体健康和生活质量。心室重构在心力衰竭的发生和发展中起着关键作用。因此，通过改善心室重构，探讨中医药干预心力衰竭的发展具有重要的研究价值。研究表明，多种信号通路的介导会导致心室重构进行性加重，并且实验研究也经常证实中药的治疗作用。中医通常通过多种靶标和多种途径来实现心力衰竭的治疗效果。近年来，中医药干预心力衰竭的作用及其机制的研究越来越多，但总结中药干预对心力衰竭信号通路的影响较少，现就中医药对心力衰竭的认识、中医药干预心力衰竭相关的5条信号通路进行综述，即转化生长因子-β1(TGF-β1)/信号转导蛋白（Smads）信号通路、Toll样受体（TLR）/核转录因子-κB(NF-κB)炎症信号通路、肾素-血管紧张素-醛固酮（RAAS）系统、磷酸肌醇3-激酶（PI3K）-丝氨酸/苏氨酸蛋白激酶（AKT）信号通路及丝裂原活化蛋白激酶（MAPK）依赖性信号通路。
Abstract：Heart failure(HF) is a kind of continuous development syndrome of cardiac insufficiency caused by various heart diseases. Not only does the prevalence continue to rise, but the mortality rate and readmission rate remain high. Heart failure is also the end-stage of cardiovascular disease and the main cause of death of patients, which seriously affects the health and quality of life of people all over the world. Ventricular remodeling plays a key role in the occurrence and development of heart failure. Therefore, by improving ventricular remodeling, it is of important research value to explore the intervention of traditional Chinese medicine in the development of heart failure. Studies have shown that the mediation of multiple signaling pathways can lead to progressive aggravation of ventricular remodeling, and experimental studies often confirm the therapeutic effects of traditional Chinese medicine. Traditional Chinese medicine usually achieves the therapeutic effect of heart failure through multiple targets and multiple approaches. In recent years, there have been more and more researches on the role and mechanism of Chinese medicine intervention in heart failure. However, it is concluded that Chinese medicine intervention has less influence on heart failure signal pathways. This article summarizes the understanding of Chinese medicine on heart failure and the five signal pathways related to Chinese medicine intervention in heart failure. The 5 signaling pathways in the world, namely transforming growth factor-β1( TGF-β1)/signal transduction protein( Smads) signaling pathway, Toll-like receptor( TLR)/nuclear transcription factor-κB( NF-κB) inflammation signaling pathway, Renin-angiotensin-aldosterone( RAAS) system, phosphoinositide 3-kinase( PI3K)-serine/threonine protein kinase( AKT) signaling pathway and mitogen-activated protein kinase( MAPK) dependent signaling pathway.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20210827.003
中图分类号:R259
引用信息:
[1]刘龙燕,卢健棋,陈文鹏,等.中医药防治心力衰竭相关信号通路研究进展[J].海南医学院学报,2023,29(12):954-960.DOI:10.13210/j.cnki.jhmu.20210827.003.
基金信息:
国家自然科学基金项目（81673891,81560760）; 广西医疗卫生适宜技术研究与开发项目（S2015 32）; 广西中药壮瑶药制剂提升工程项目（GZZJ16-03）~~
2021-08-27
2021-08-27
2021-08-27