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目的:研究妊娠期糖尿病孕妇血清维生素D水平与糖脂代谢特征、炎性因子分泌的相关性。方法:选择我院在2015年3月～2018年2月期间诊断的GDM孕妇作为GDM组,同期进行产检并分娩的健康孕妇作为对照组。采集孕24周时的空腹静脉血,测定25(OH)D3、糖脂代谢指标、炎性因子的含量;采集分娩后的胎盘组织,测定生物信号分子的mRNA表达量。结果:GDM孕妇的血清25(OH)D3、HDL-C、apoA1/apoB、APN、Omentin-1以及胎盘GLUT3、GLUT4、IRS-1的mRNA表达量明显低于对照组,血清F-INS、HOMA-IR、LDL-C、IL-6、TNF-α以及胎盘TLR4、NF-κB的mRNA表达量明显高于对照组;GDM孕妇的血清25(OH)D3与血清HDL-C、apoA1/apoB、APN、Omentin-1以及胎盘GLUT3、GLUT4、IRS-1的mRNA表达量呈正相关,与血清F-INS、HOMA-IR、LDL-C、IL-6、TNF-α以及胎盘TLR4、NF-κB的mRNA表达量呈负相关。结论:GDM孕妇血清维生素D水平的降低与糖脂代谢紊乱、炎性因子异常分泌密切相关。
Abstract：Objective: To study the correlation between serum vitamin D levels with glycolipid metabolism, inflammatory factors secretion in pregnant women with gestational diabetes mellitus(GDM). Methods: GDM pregnant women diagnosed in our hospital from March 2015 to February 2018 were selected as GDM group, and healthy pregnant women who underwent obstetric examination and delivered at the same time were selected as control group. Fasting venous blood was collected at 24 weeks of gestation and 25(OH) D3, glucose and lipid metabolism indexes, inflammatory factors were measured. The placenta tissues after delivery were collected and the mRNA expression of biological signal molecules were measured. Results: Serum 25(OH) D3, HDL-C, apoA1/apoB, APN, Omentin-1 and mRNA expression of GLUT3, GLUT4, IRS-1 in placenta of GDM group were significantly lower than those in control group, serum F-INS, HOMA-IR, LDL-C, IL-6, TNF-a and the mRNA expressions of TLR4, NF-κB in placenta were significantly higher than those in control group. Serum 25(OH) D3 of GDM group was positively correlated with serum HDL-C, apoA1/apoB, APN, Omentin-1 and mRNA expression of GLUT3, GLUT4, IRS-1 in placenta, whereas negatively correlated with serum F-INS, HOMA-IR, LDL-C, IL-6, TNF-a and the mRNA expressions of TLR4, NF-κB in placenta. Conclusion: The decrease of serum vitamin D level in GDM pregnant women closely correlates with the disorder of glucose and lipid metabolism and abnormal secretion of inflammatory factors.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20190318.003
中图分类号:R714.256
引用信息:
[1]梁秋萍,叶燕玲,肖楚艳.妊娠期糖尿病孕妇血清维生素D水平与糖脂代谢特征、炎性因子分泌的相关性[J].海南医学院学报,2019,25(09):666-669+673.DOI:10.13210/j.cnki.jhmu.20190318.003.
基金信息:
中山市医学科研项目(2016A020241)~~
2019-03-20
2019-03-20
2019-03-20