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能量代谢紊乱是心力衰竭进展中的一大病理改变，该过程导致心肌产能不足，进一步加重心功能障碍，而以葡萄糖和脂肪酸为主的代谢底物利用紊乱在这过程中起重要作用。近些年来的研究表明以益气温阳为主要作用的一些中药或复方在调节能量代谢紊乱方面有很好的效果，发现中药中的一些有效成分能够调节心肌细胞代谢底物的摄取和利用，使心肌细胞的代谢在缺氧条件下朝有利于机体的方向调整，增加心肌总体能量供给，改善心功能。本文就中药干预心衰心肌细胞糖脂代谢研究进行综述，初步总结中药干预心衰心肌葡萄糖和脂肪酸代谢的规律和机制，以期从中医药角度为能量代谢疗法的研究提供线索。
Abstract：Disorder of energy metabolism is a major pathological change in the progression of heart failure. This process leads to insufficient myocardial energy and further aggravates cardiac dysfunction. Disorders of metabolic substrate utilization,mainly glucose and fatty acids,play an important role in this process. Research over the years has shown that some traditional Chinese medicines or compound prescriptions whose main role is to replenish qi and warm yang have good effects in regulating energy metabolism disorders. It has been found that some active ingredients in traditional Chinese medicine can regulate the uptake and utilization of myocardial cell metabolic substrate,so that the metabolism of myocardial cells can be adjusted in a direction that is beneficial to the body under hypoxic conditions,increasing the overall energy supply of the myocardium and improving heart function.This article reviewed the research of traditional Chinese medicine intervention on glucose and lipid metabolism of heart failure myocardial cells,and preliminarily summarizes the law and mechanism of traditional Chinese medicine intervention in heart failure myocardial glucose and fatty acid metabolism,hoping to provide clues for energy metabolism therapy research from the perspective of traditional Chinese medicine.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20210419.004
中图分类号:R259
引用信息:
[1]王晓琳,车驰,陈智勇,等.中药对心力衰竭心肌糖脂代谢干预的研究进展[J].海南医学院学报,2022,28(16):1275-1280.DOI:10.13210/j.cnki.jhmu.20210419.004.
基金信息:
国家自然科学基金资助项目（81960820）; 江西省自然科学基金资助项目（20202BABL206141）~~
2021-04-19
2021-04-19
2021-04-19