海南医科大学学报

目的：系统评价益气化痰祛瘀法治疗慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的疗效。方法：检索中国知网(CNKI)、维普中文科技期刊数据库(VIP)、万方数据知识服务平台(Wanfang)、中国生物医学文献数据库(CBM)、PubMed、Embase、Cochrane Library、Web of Science数据库，筛选符合益气化痰祛瘀法治疗AECOPD纳入标准的文献，使用RevMan 5.4软件进行统计学分析。结果：共纳入文献10篇，共计854例患者，治疗组435例，对照组419例。通过系统分析，益气化痰祛瘀法联合西医常规治疗AECOPD较单用西医常规治疗在临床总有效率方面有明显差异性[OR=3.98,95%CI(2.23,7.11),P<0.000 01]；肺功能方面FEV₁/FVC[MD=6.08,95%CI(5.01,7.15),P<0.000 01]、FEV₁[MD=0.07,95%CI(0.01,0.13),P=0.02]、FEV₁%[MD=4.56,95%CI(3.09,6.02),P<0.000 01]较对照组明显增强；动脉血氧分压(PaO₂)[MD=18.47,95%CI(16.77,20.16),P<0.000 01]较对照组明显改善；动脉血二氧化碳分压(PaCO₂)[MD=-7.48,95%CI(-8.70，-6.26),P<0.000 01]较对照组明显降低。结论：益气化痰祛瘀法联合西医常规治疗AECOPD能够提高临床疗效，改善患者生活质量。

Objective:To systematically evaluate the efficacy of the method of tonifying qi,resolving phlegm and eliminating stasis in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods:The databases such as the CNKI,VIP,Wanfang,China Biomedical Literature Database(CBM),PubMed,Embase,Cochrane Library and Web of Science were searched to select the literature on the method of tonifying qi,resolving phlegm and eliminating stasis in the treatment of AECOPD. RevMan 5.4 software was used for statistical analysis. Results:A total of 10 articles were included,with a total of 854 patients,435 in the treatment group and 419 in the control group. Systematic analysis showed that the method of tonifying qi,resolving phlegm and eliminating stasis combined with conventional western medicine in the treatment of AECOPD significantly improved total clinical effective rate compared with conventional western medicine treatment alone[OR=3.98,95%CI(2.23,7.11),P<0.000 01]. In terms of lung function,FEV₁/FVC[MD=6.08,95%CI(5.01,7.15),P<0.000 01],FEV₁[MD=0.07,95%CI(0.01,0.13),P=0.02],and FEV₁%[MD=4.56,95%CI(3.09,6.02),P<0.000 01]were significantly higher than the control group. Arterial oxygen partial pressure(PaO₂)[MD=18.47,95%CI(16.77,20.16),P<0.000 01]was significantly improved compared to the control group,and arterial partial pressure of carbon dioxide(PaCO₂)[MD=-7.48,95%CI(-8.70,-6.26),P<0.000 01]was significantly lower than the control group. Conclusion:The current evidence shows that the method of tonifying qi,resolving phlegm and eliminating stasis combined with conventional western medicine in acute exacerbations can improve clinical efficacy and the quality of life of AECOPD patients.