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目的:探讨乌司他丁联合奥曲肽治疗对重症胰腺炎患者全身炎症反应、肠黏膜功能的影响。方法:选择我院收治的82例重症胰腺炎患者,回顾治疗方案,并分为对照组43例、乌司他丁组39例,对照组接受常规+奥曲肽治疗,乌司他丁组接受常规+奥曲肽+乌司他丁治疗,均持续1周。对比两组患者治疗前后全身炎症反应、肠黏膜功能的差异。结果:治疗前,两组血清中炎症介质、肠黏膜功能指标含量的差异无统计学意义(P>0.05)。治疗1周后,乌司他丁组患者血清中炎症介质IL-1β、IL-8、HMGB-1、MCP-1的含量以及肠黏膜功能指标ET、DAO、D-lactose的含量低于对照组(P<0.05)。结论:重症胰腺炎患者在常规治疗基础上加入乌司他丁联合奥曲肽治疗,可进一步抑制机体全身炎症反应同时积极保护肠黏膜功能。
Abstract：Objective:To investigate the effects of ulinastatin combined with octreotide therapy on systemic inflammatory response and intestinal mucosal function in patients with severe pancreatitis.Methods:82 patients with severe pancreatitis who were treated in our Hospital between March 2015 and August 2017 were reviewed and divided into control group(n=43)and ulinastatin group(n=39),control group received conventional+ octreotide therapy,ulinastatin group received conventional+ octreotide+ ulinastatin therapy,and both groups were treated for 1 week.The differences in systemic inflammatory response and intestinal mucosal function were compared between the two groups before and after treatment.Results:Before treatment,the differences in serum levels of inflammatory mediators and intestinal mucosal function indexes were not statistically significant between the two groups.After 1 week of treatment,serum levels of inflammatory mediators IL-1β,IL-8,HMGB-1 and MCP-1 as well as intestinal mucosal function indexes ET,DAO and D-lactose of ulinastatin group were lower than those of control group.Conclusion:Ulinastatin combined with octreotide therapy on the basis of conventional treatment can further inhibit the systemic inflammatory response and actively protect the intestinal mucosal function in patients with severe pancreatitis.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20171211.007
中图分类号:R576
引用信息:
[1]李革红.乌司他丁联合奥曲肽治疗对重症胰腺炎患者全身炎症反应、肠黏膜功能的影响[J].海南医学院学报,2017,23(24):3373-3376.DOI:10.13210/j.cnki.jhmu.20171211.007.
基金信息:
凉山州科技局课题(12YYJS0092)~~
2017-12-11
2017-12-11
2017-12-11