| 52 | 5 | 11 |
| 下载次数 | 被引频次 | 阅读次数 |
目的:探究及分析重组人脑利钠肽对体外循环心脏直视手术患者心肌酶、血清心功能指标及氧代谢的影响。方法:选取本院收治的42例体外循环心脏直视手术患者随机分为对照组21例和观察组21例,对照组进行常规术后治疗,观察组则在对照组的基础上加用重组人脑利钠肽,然后将两组术前及术后2、12、24h心肌酶、血清心功能指标及氧代谢指标进行分别检测与比较。结果:术前两组心肌酶、血清心功能指标及氧代谢指标比较,差异无统计学意义(P>0.05),而术后2、12h及24h观察组的心肌酶及血清心功能指标均低于对照组,氧代谢指标均好于对照组(P<0.05)。结论:重组人脑利钠肽可有效改善体外循环心脏直视手术患者的心肌酶、血清心功能指标及氧代谢状态,对于此类手术患者的应用价值相对较高。
Abstract：Objective:To investigate and analyze the degree of influence of recombinant human brain natriuretic peptide for the myocardial enzymes,serum cardiac function indexes and oxygen metabolism of patients with open heart surgery with cardiopulmonary bypass.Methods:A total of 42 patients underwent open heart surgery with cardiopulmonary bypass were randomly divided into the control group(n=21cases)and the observation group(n=21cases).The control group was treated with routine postoperative treatment,and the observation group was treated with recombinant human brain natriuretic peptide on the basic treatment of control group,then the myocardial enzymes,serum cardiac function indexes and oxygen metabolism indexes of the two groups before the surgery and at 2h,12 hand 24hafter the surgery were respectively detected and compared.Results:The myocardial enzymes,serum cardiac function indexes and oxygen metabolism indexes of two groups before the surgery were not significantly different(all P>0.05),while the myocardial enzymes and serum cardiac function indexes of the observation group at 2h,12 hand 24hafter the surgery were all lower than those of control group,the oxygen metabolism indexes were better than the levels of control group(Pall<0.05).Conclusion:The recombinant human brain natriuretic peptide can effectively improve the myocardial enzymes,serum cardiac function indexes and oxygen metabolism state of patients who underwent open heart surgery with cardiopulmonary bypass,and its application value for the patients with the surgery is higher.
1曾国平,田劲松,段世英.重组人脑利钠肽治疗急性心肌梗死后心力衰竭的疗效观察[J].中国医药导报,2012,9(3):44-45.
2 曹东来,韩冷,倪杰,等.重组人脑利钠肽对急性心肌梗死伴心力衰竭患者血清CK-MB、TnI的影响[J].实用临床医药杂志,2014,18(23):14-16.
3 魏军,董丽华.重组人脑利钠肽治疗冠心病失代偿性心力衰竭的疗效观察及护理[J].中国伤残医学,2014,22(24):197-199.
4 孙立智,吴智宏,李霞,等.全麻对非体外循环冠状动脉旁路移植术患者血流动力学与氧代谢的影响[J].现代中西医结合杂志,2016,25(3):251-253.
5 Zhang Y,Gao F,Zhang XY,et al.Value of human brain natriuretic peptide in treatment of acute anterior myocardial infarction evaluated via three-dimensional speckle tracking imaging[J].Genet Mol Res,2015,14(2):5699-5709.
6 方传奇.全程七氟醚维持麻醉对心脏手术患者体外循环缺血再灌注损伤心肌的影响[J].国际医药卫生导报,2016,22(3):314-316.
7 杨威,董啸.前B细胞克隆增强因子在体外循环术后肺血管内皮通透性增加中的机制研究[J].临床医学工程,2016,23(1):22-24.
8 Bernardi MH,Rinoesl H,Dragosits K,et al.Effect of hemoadsorption during cardiopulmonary bypass surgery-a blinded,randomized,controlled pilot study using a novel adsorbent[J].Crit Care,2016,20(1):96.
9 黄国晖,陈伟,孙广龙,等.冠脉搭桥术围术期心肌损伤相关指标和血小板活化研究[J].海南医学院学报,2012,18(11):1614-1616.
10 杨红伟,王祖辉,陈恒,等.体外循环术中血糖浓度对术后脑损伤的影响[J].海南医学院学报,2014,20(8):1123-1125.
11 林国强,罗万俊,李迎秋,等.重组人脑利钠肽对体外循环心脏瓣膜置换术患者血浆内毒素及全身炎性反应的影响[J].中华胸心血管外科杂志,,2012,28(5):66-67.
基本信息:
DOI：10.13210/j.cnki.jhmu.20160602.011
中图分类号:R654.2
引用信息:
[1]宋书田,杨明,李鲲鹏,等.重组人脑利钠肽对体外循环心脏直视手术患者心肌酶、血清心功能指标及氧代谢的影响[J].海南医学院学报,2016,22(17):1966-1968.DOI:10.13210/j.cnki.jhmu.20160602.011.
基金信息:
2015年度河北省沧州市科学技术研究与发展指导计划项目(151302044)~~
2016-06-02
2016-06-02
2016-06-02