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目的:分析氟西汀治疗广泛性焦虑症(GAD)的疗效及其对血清疾病相关指标的影响。方法:将120例GAD随机分为两组,对照组和观察组各60例。对照组采用地西泮治疗,观察组则采用氟西汀治疗。治疗前及治疗后第2、4、6周采用汉密尔顿焦虑量表(HAMA)进行评分,比较两组间疗效差异;同时对血清神经递质肾上腺素(EPH)、去甲肾上腺素(NE)、5-羟色胺(5-HT)、多巴胺(DA)水平及免疫功能相关指标免疫球蛋白IgG,IgA,IgM和白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平进行检测,比较组间差异。结果:治疗后第2、4、6周,观察组HAMA总分、MA和PA得分均明显低于对照组,差异具有统计学意义(P<0.05);治疗6周后,观察组血清EPH、NE、5-HT和DA、TNF-α水平均明显低于对照组,而IL-2和IgG,IgA,IgM水平均高于对照组,差异具有统计学意义(P<0.05)。结论:氟西汀能有效改善GAD血清疾病相关指标,治疗GAD疗效优于地西泮。
Abstract：Objective:To analyze the efficacy of fluoxetine on patients with generalized anxiety disorder(GAD),and on serum disease indicators.Methods:A total of 120 cases with GAD were randomly divided into two group,the control group and the observation group by half.Patients in control group were treated with diazepam,and patients in observation group were treated with fluoxetine.HAMA was used to evaluate the efficacy score,and the serum levels of neurotransmitters such as Epinephrine(EPH),norepinephrine(NE),5-serotonin(5-HT),dopamine(DA)and immune function related indicators such as immunoglobulins IgG,IgA,IgM,and interleukin-2(IL-2),tumor necrosis factor-α(TNF-α)were detected and compared.Results:2,4,6 weeks after treatment,HAMA total score,MA and PA score of observation group were significantly lower than control group.The serum levels of EPH,NE,5-HT and DA,TNF-αwere significantly higher than the control group,while the serum levels of IL-2 and IgG,IgA,IgM were significantly higher than the control group(P<0.05).Conclusion:Fluoxetine can effectively improve serum disease-related indicators in patients with GAD.Treatment efficacy of fluoxetine is superior to diazepam in GAD.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20141114.007
中图分类号:R749.72
引用信息:
[1]唐琴.氟西汀在广泛性焦虑症中的疗效及对血清疾病指标的影响[J].海南医学院学报,2015,21(02):268-270.DOI:10.13210/j.cnki.jhmu.20141114.007.
基金信息:
成都市卫生局资助基金:291872293~~
2014-11-14
2014-11-14
2014-11-14