海南医科大学学报

目的:探讨血清肿瘤标志物癌胚抗原(CEA)、糖类抗原125(CA125)、神经元特异性烯醇化酶(NSE)和细胞角质蛋白19片段(CYFRA21-1)在肺癌诊断中的意义。方法:分别应用化学发光和电化学发光技术检测肺癌患者(50例)、肺良性疾病患者(38例)及健康对照组(42例)的血清CEA、CA125、NSE和CYFRA21-1的表达水平,并进行比较。结果:肺癌组血清CEA、CA125、NSE、CYFRA21-1表达水平明显高于肺良性疾病组和健康对照组,差异有统计学意义(P均<0.05);肺癌组血清4种标志物阳性率高于良性疾病组和健康对照组,在肺腺癌中CEA和CA125阳性率均为55.6%,小细胞肺癌NSE阳性率为87.5%,肺鳞癌CYFRA21-1阳性率为80.0%;4种肿瘤标志物联合检测与单个项目比较,敏感度和准确度都有显著提高。结论:联合检测血清肿瘤标志物CEA、CA125、NSE和CYFRA21-1可提高对肺癌诊断的敏感度和准确度,且可鉴别肺癌的病理类型。

Objective:To discuss the value of serum tumor markers CEA,CA125,NSE and CYFRA21-1 in diagnosing lung cancer.Methods:The serum levels of CEA,CA125,NSE and CYFRA21-1 were measured by chemiluminescence immunoassay(CLIA) and electrochemiluminescence immunoassay(ECLIA) in 50 patients with lung cancer,38 patients with benign lung diseases and 42 healthy persons.The data was analyzed by the statistical SPSS13.0 software.Results:Serum levels and positive rates of four tumor markers in patients with lung cancer were significantly higher in cancer group than that in benign pulmonary disease group and healthy control group(P<0.05).The positive rates of CEA and CA125 were 55.6% in patients with adenocarcinoma of lung,rate of NSE was 87.5% in small cell lung cancer,and rate of CYFRA21-1 was 80.0% in squamous cell carcinoma.Compared to single detection,the sensitivity and accuracy of combined detection of the four tumor markers were improved significantly.Conclusions:Combined detection of serum tumor markers CEA,CA125,NSE and CYFRA21-1 can improve the sensitivity and accuracy of lung cancer diagnosis and contribute to the pathological type identification of lung cancer.