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目的:探讨支气管哮喘患儿血清免疫球蛋白E(IgE)及T淋巴细胞亚群的动态变化及临床意义。方法:45例支气管哮喘患儿设为哮喘组,同期健康体检儿童35例设为对照组,检测哮喘组急性发作期、缓解期及对照组的T淋巴细胞亚群、总IgE含量。结果:哮喘组急性发作期CD3+CD4+细胞含量及CD4+/CD8+比值显著高于对照组(P<0.01),总IgE含量显著高于对照组(P<0.01),缓解期较急性发作期显著改善(P<0.01),但与对照组仍有显著差异(P<0.01);随访1年期间,哮喘发作次数得分平均(3.56±1.07)分,发作严重程度得分平均(5.19±2.47)分;pearson相关性分析表明总IgE含量与哮喘发作次数呈正相关(r=0.562,P<0.01)。结论:支气管哮喘患儿外周血中辅助性T淋巴细胞含量降低,总IgE含量升高,两者在哮喘发生、发展中具有重要意义。
Abstract：Objective:To investigate the dynamic changes and clinical significance of serum immunoglobulin E(IgE)and T lymphocytes in children with bronchial asthma.Methods:A total of 45 children with bronchial asthma served as asthma group while another 35 healthy children undergoing physical examination as control group.Subgroups of T lymphocytes and IgE levels in onset and remission stages in asthma group and control group were detected.Results:CD3+CD4+cell levels,ratio of CD4+/CD8+and total IgE level were evidently higher in onset stage in asthma group than in control group(P<0.01),which were also significantly improved at remission stage(P<0.01),and the differences were significant when compared with control group(P<0.01).After 1-year follow up,the average attack frequency score and severity score of asthma were(3.56±1.07)and(5.19±2.47)scores,respectively.Pearson relevance analysis showed that total IgE level was in positive association with the attack frequency of asthma(r=0.562,P<0.01).Conclusions:The complementary T lymphocytes are decreased and total IgE level increased significantly in the peripheral blood of children with bronchial asthma,both of which are of great importance in the development and progression of asthma.
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基本信息:
DOI：10.13210/j.cnki.jhmu.20150121.003
中图分类号:R725.6
引用信息:
[1]李建木,李琼林.支气管哮喘患儿血清免疫球蛋白E及T淋巴细胞亚群的动态变化[J].海南医学院学报,2015,21(03):313-315.DOI:10.13210/j.cnki.jhmu.20150121.003.
基金信息:
中国高校医学期刊临床专项资金(11321425)~~
2015-01-21
2015-01-21
2015-01-21