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目的:探讨加减平积汤对子宫肌瘤患者雌、孕激素受体,性激素、胰岛素生长因子-I及其受体水平的影响。方法:选择我院2015年1月~2017年1月收治的90例子宫肌瘤患者,随机分为对照组和治疗组,每组各有病例45例。给予对照组患者米非司酮治疗,给予治疗组患者加减平积汤联合米非司酮治疗,两组均连续给予治疗3个月。测量并比较两组患者治疗前后子宫肌瘤体积和子宫体积。检测并比较两组患者治疗前后血清雌激素受体(ER)、孕激素受体(PR)、孕酮(P)、雌二醇(E2)、黄体生成激素(LH)、卵泡生成激素(FSH)、胰岛素生长因子-Ⅰ(IGF-Ⅰ)、胰岛素生长因子-Ⅰ受体(IGF-ⅠR)水平。结果:两组治疗前子宫肌瘤体积和子宫体积比较,无显著性差异(P>0.05);两组治疗后子宫肌瘤体积和子宫体积相比治疗前均较小,且治疗组治疗后的子宫肌瘤体积和子宫体积均明显小于对照组,差异均具有统计学意义(P<0.05)。两组治疗前血清ER、PR、P、E2、LH、FSH、IGF-Ⅰ、IGF-ⅠR水平比较,无显著性差异(P>0.05);两组治疗后血清ER、PR、P、E2、LH、FSH、IGF-I、IGF-IR水平相比治疗前较低,且治疗组治疗后血清ER、PR、P、E2、LH、FSH、IGF-I、IGF-IR水平均小于对照组,差异均具有统计学意义(P<0.05)。结论:加减平积汤联合米非司酮能够明显缩小子宫肌瘤患者的瘤体,改善雌、孕激素受体,性激素、胰岛素生长因子-I及其受体水平,值得在临床上推广应用。
Abstract：Objective:To study the effect of Jia jian-ping ji decoction on serum ER,PR,sex hormone,IGF-Ⅰ and IGFI in patients with uterine fibroids.MethodsA total of 90 patientswith uterine fibroids in our hospital from January 2015 to January 2017 were enrolled in this study.The subjects were divided into the control group(n=45)and the treatment group(n=45)randomly.The control group were treated withmifepristone,the treatment group were treated withJia jian-ping ji decoctioncombined with mifepristone,and both the two groups were treated for 3 months.The uterine fibroid volume and uterine volumeof the two groups before and after treatment were compared.The serum ER,PR,P,E2,LH,FSH,IGF-Ⅰ and IGF-IR of the two groups before and after treatment were compared.Results There were no significantly differences of the uterine fibroid volume and uterine volumeof the two groups beforetreatment(P>0.05).The uterine fibroid volume and uterine volumeof the two groups after treatment were significantly less than before treatment(P<0.05),and that of the treatment group after treatment were significantly less than the control group(P<0.05).There were no significantly differences of the serum ER,PR,P,E2,LH,FSH,IGF-Ⅰ and IGF-IR of the two groups beforetreatment(P>0.05).The serum ER,PR,P,E2,LH,FSH,IGF-Ⅰ and IGF-IR of the two groups after treatment were significantly lower than before treatment(P<0.05),and that of the treatment group after treatment were significantly lower than the control group(P<0.05).ConclusionJia jian-ping ji decoctioncombined with mifepristonecan significantly reduce the uterine fibroid volume,improvethe serum ER,PR,sex hormone,IGF-Ⅰ and IGF-Ⅰ levels of the patients withuterine fibroids,and it was worthy clinical application.
1 Chittawar PB,Kamath MS.Review of nonsurgical/minimally invasive treatments and open myomectomy for uterine fibroids[J].Curr Opin Obstet Gynecol,2015,27(6):391-397.
2 Vitale SG,Padula F,Gulino FA,et al.Management of uterine fibroids in pregnancy:recent trends[J].Curr Opin Obstet Gynecol,2015,27(6):432-437.
3 陈庆云,张小燕.子宫肌瘤发病机制研究进展[J].中国实用妇科与产科杂志,2012,28(12):950-952.
4 Markowski DN,Holzmann C,Bullerdiek J.Genetic alterations in uterine fibroids-a new direction for pharmacological intervention?[J].Expert Opin Ther Targets,2015,19(11):1485-1494.
5 王瑞婷,须义贞,梁阿娟,等.子宫肌瘤发病的相关因素和中医证型研究[J].吉林中医药,2017,37(6):571-574.
6 Thiburce AC,Frulio N,Hocquelet A,et al.Magnetic resonanceguided high-intensity focused ultrasound for uterine fibroids:Mid-term outcomes of 36patients treated with the Sonalleve system[J].Int J Hyperthermia,2015,1(7):764-770.
7 赵奕奕,刘晶珠.米非司酮对拟行子宫肌瘤切除术患者相关指标的影响[J].中国药房,2017,28(18):2492-2495.
8 乐杰.妇产科学[M].6版.北京:人民卫生出版社,2005:295-298.
9 Geale K,Hultberg M,Henriksson M.Applying symptom-based utility functions in health economic modelling:A case study of uterine fibroids[J].Value Health,2015,18(7):728.
10 郑真真,孙静.子宫肌瘤的治疗进展[J].海南医学,2014,25(3):383-386.
11 郭俊风.米非司酮不用用药途径治疗子宫肌瘤的临床观察[J].中国医药指南,2016,14(19):48-49.
12 陈晨.中医活血化瘀法治疗子宫肌瘤的临床分析[J].中国现代药物应用,2014,8(11):235-236.
13 钱麟,齐聪,张勤华.补肾消瘤方治疗80例子宫肌瘤临床疗效分析[J].实用诊断与治疗杂志,2007,21(8):574-576.
14 徐圣强,徐新建,俞行.血府逐瘀汤加减治疗子宫肌瘤介入术后月经紊乱140例[J].浙江中西医结合杂志,2007,13(5):300-301.
15 李灵芝,李桂华,陈萍.散结消瘤汤治疗子宫肌瘤临床疗效观察[J].天津中医药,2003,20(5):22-23.
16 欧碧荷,蓝春花.桂枝茯苓胶囊联合米非司酮治疗子宫肌瘤临床观察[J].辽宁中医杂志,2015,42(3):551-553.
17 倪平.自拟消积汤治疗子宫肌瘤47例[J].黑龙江中医药,1999,4:40.
18 章华丽,时燕萍,王莉琳.平积汤方对子宫肌瘤患者宫内膜中雌孕激素受体(ER、PR)表达的影响[J].辽宁中医药大学学报,2011,13(10):100-101.
19 封全灵,王智霆,刘慧云.子宫肌瘤细胞中孕激素受体M、A/B及porin蛋白表达观察[J].山东医药,2017,57(15):45-47.
20 刘爱萍.外周血胰岛素样生长因子-Ⅰ和Ⅱ水平与子宫肌瘤组织中雌孕激素受体的关系研究[J].中国妇幼保健,2017,32(13):3047-3049.
21 李黎明,杨艳,于静.活血化瘀方联合米非司酮治疗子宫肌瘤88例[J].南京中医药大学学报,2015,31(4):334-336.
基本信息:
DOI：10.13210/j.cnki.jhmu.20171027.005
中图分类号:R737.33
引用信息:
[1]李伊莎,陈璐,刘丹.加减平积汤对子宫肌瘤患者雌、孕激素受体,性激素、胰岛素生长因子-Ⅰ及其受体水平的影响[J].海南医学院学报,2017,23(21):2945-2948.DOI:10.13210/j.cnki.jhmu.20171027.005.
基金信息:
湖北省科技计划项目(2015SN1269)~~
2017-10-27
2017-10-27
2017-10-27